Maleimide Activated hOVA *Optimized for Maximum Immunization Response*

Maleimide Activated hOVA

Optimized for Maximum Immunization Response

Maleimide-activated hOVA is a sulfhydryl-reactive derivative designed for optimal hapten-carrier conjugation with cysteine-containing peptides and other thiolated antigens. This product consists of purified ovalbumin (cOVA) modified with an SMCC crosslinker, introducing maleimide groups that form stable covalent bonds with sulfhydryl groups on cysteine residues. This modification ensures precise conjugation, allowing the attachment of multiple antigens per carrier molecule without epitope interference. Hexamethylenediamine-modified ovalbumin (hOVA) is produced by treating native ovalbumin with hexamethylenediamine, replacing most negatively charged carboxyl groups with positively charged primary amines. This modification yields a highly positively charged hOVA, significantly enhancing the immunogenicity of the ovalbumin. Furthermore, the increased number of primary amines provides additional conjugation sites for hapten molecules, thus improving the versatility of standard conjugation techniques. Despite its increased hydrophobicity and reduced solubility in aqueous buffers compared to Bovine Serum Albumin (BSA), hOVA remains soluble in up to 70% DMSO. This solubility makes it particularly suitable for conjugation with haptens requiring DMSO for solubility.

General packaging for Cat. No. 5611. Your actual packaging may differ.

Datasheet

SDS

COA

Catalog	Size	Price	Quantity
5611	5 x 1 mg	Price

References

View all 50 references: Citation Explorer

Delivery of mRNA Vaccine with 1, 2-Diesters-Derived Lipids Elicits Fast Liver Clearance for Safe and Effective Cancer Immunotherapy.

Authors:

Xu, Yuandong and Hu, Yuexiao and Xia, Heng and Zhang, Shiqiang and Lei, Hanqi and Yan, Binyuan and Xiao, Ze Xiu and Chen, Jinjin and Pang, Jun and Zha, Gao-Feng

Journal:

Advanced healthcare materials (2024): e2302691

Novel TLR4-Activating Vaccine Adjuvant Enhances the Production of Enterococcus faecium-binding Antibodies.

Authors:

Franco, Ana Rita and Sadones, Océane and Romerio, Alessio and Artusa, Valentina and Shaik, Mohammed Monsoor and Pasco, Samuel T and Italia, Alice and D'Amato, Simona and Anguita, Juan and Huebner, Johannes and Romero-Saavedra, Felipe and Peri, Francesco

Journal:

Journal of medicinal chemistry (2024): 5603-5616

Intact Transition Epitope Mapping-Serological Inspection by Epitope EXtraction (ITEM-SIX).

Authors:

Zammataro, Agatino and Koy, Cornelia and Ruß, Manuela and Röwer, Claudia and Glocker, Michael O

Journal:

Molecules (Basel, Switzerland) (2023)

Intervention effects of Trichinella spiralis excretory-secretory antigens on allergic asthma in mice.

Authors:

Zhen, Jing-Bo and Zhang, Jin-Peng and Sun, Feng and Lin, Li-Hao and Zhang, Yu-Heng and Wang, Rui-Biao and Han, Yang and Li, Zhi-Xin and Lu, Yi-Xin

Journal:

International immunopharmacology (2023): 110101

Human leukocyte antigen HLA-DR-expressing fibroblast-like synoviocytes are inducible antigen presenting cells that present autoantigens in Lyme arthritis.

Authors:

Rouse, Joseph R and Danner, Rebecca and Wahhab, Amanda and Pereckas, Michaela and McClune, Mecaila E and Steere, Allen C and Strle, Klemen and Jutras, Brandon L and Lochhead, Robert B

Journal:

bioRxiv : the preprint server for biology (2023)

Physical properties

Solvent

Water

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C)
UNSPSC	12171501

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Page updated on April 26, 2026