Name: Mca-PLAQAV-Dpa-RSSSR-NH2
Brand: AAT Bioquest
SKU: 13560
Price: 165 USD
Availability: InStock

Mca-PLAQAV-Dpa-RSSSR-NH2

Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorogenic peptide substrate for detecting tumor necrosis factor-alpha converting enzyme (TACE or ADAM17) and related enzymes such as ADAM8, ADAM9 and ADAM10. Its N-terminal contains a highly fluorescent 7-methoxycoumarin (MCA) fluorophore that is efficiently quenched by non-fluorescent 2,4-dinitrophenyl group on Dpa via fluorescence resonance energy transfer (dark FRET). It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, resulting an increase in fluorescence. The peptide sequence is derived from the pro tumor necrosis factor-alpha (TNF-alpha). The cleavage site by TACE/ADAM17 and ADAM10 is the peptide bond between A (Ala) and V (Val) residues.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
13560	1 mg	Price

References

View all 13 references: Citation Explorer

Increased plasma TACE activity in subjects with mild cognitive impairment and patients with Alzheimer's disease.

Authors:

Sun, Qiying and Hampel, Harald and Blennow, Kaj and Lista, Simone and Levey, Allan and Tang, Beisha and Li, Rena and Shen, Yong

Journal:

Journal of Alzheimer's disease : JAD (2014): 877-86

Primary structure and characterization of a non hemorrhagic metalloproteinase with fibrinolytic activity, from the snake venom of Protobothrops tokarensis (Tokara-habu).

Authors:

Oyama, Etsuko and Kitagawa, Yasuyuki and Takahashi, Hidenobu

Journal:

Toxicon : official journal of the International Society on Toxinology (2013): 153-61

Expression of pro-inflammatory TACE-TNF-α-amphiregulin axis in Sjögren's syndrome salivary glands.

Authors:

Sisto, Margherita and Lisi, Sabrina and Lofrumento, Dario Domenico and Ingravallo, Giuseppe and Mitolo, Vincenzo and D'Amore, Massimo

Journal:

Histochemistry and cell biology (2010): 345-53

ADAM-17: the enzyme that does it all.

Authors:

Gooz, Monika

Journal:

Critical reviews in biochemistry and molecular biology (2010): 146-69

Constitutive endocytosis of the chemokine CX3CL1 prevents its degradation by cell surface metalloproteases.

Authors:

Huang, Yi-Wei and Su, Paul and Liu, Guang Ying and Crow, Min Rui and Chaukos, Deanna and Yan, Harry and Robinson, Lisa A

Journal:

The Journal of biological chemistry (2009): 29644-53

Physical properties

Molecular weight	1638.96
Solvent	DMSO

Spectral properties

Correction factor (280 nm)	0.3
Excitation (nm)	322
Emission (nm)	381

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

Telephone
Fax
Email	sales@aatbio.com
International	See distributors
Bulk request	Inquire
Custom size	Inquire
Technical Support	Contact us
Request quotation	Request
Purchase order	Send to sales@aatbio.com
Shipping	Standard overnight for United States, inquire for international

Page updated on September 20, 2025