Name: Mca-YVADAPK(Dnp)-OH
Brand: AAT Bioquest
SKU: 13557
Price: 165 USD
Availability: InStock

Mca-YVADAPK(Dnp)-OH

Mca-YVADAPK(Dnp)-OH is a fluorogenic peptide substrate for detecting caspase-1/interleukin-converting enzyme (ICE) and angiotensin I-converting enzyme-2 (ACE-2). Its N-terminal contains a highly fluorescent 7-methoxycoumarin (MCA) fluorophore that is efficiently quenched by non-fluorescent 2,4-dinitrophenyl group on lysine residue via fluorescence resonance energy transfer (dark FRET). It can be used to measure the activities of caspase-1/interleukin-converting enzyme (ICE) and angiotensin I-converting enzyme-2 (ACE-2) that are capable of cleaving an amide bond between the fluorescent group (MCA) and the quencher group (DNP), resulting an increase in fluorescence.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
13557	1 mg	Price

References

View all 50 references: Citation Explorer

Marked Up-Regulation of ACE2 in Hearts of Patients With Obstructive Hypertrophic Cardiomyopathy: Implications for SARS-CoV-2-Mediated COVID-19.

Authors:

Bos, J Martijn and Hebl, Virginia B and Oberg, Ann L and Sun, Zhifu and Herman, Daniel S and Teekakirikul, Polakit and Seidman, Jonathan G and Seidman, Christine E and Dos Remedios, Cristobal G and Maleszewski, Joseph J and Schaff, Hartzell V and Dearani, Joseph A and Noseworthy, Peter A and Friedman, Paul A and Ommen, Steve R and Brozovich, Frank V and Ackerman, Michael J

Journal:

Mayo Clinic proceedings (2020): 1354-1368

In vitro and in vivo identification of clinically approved drugs that modify ACE2 expression.

Authors:

Sinha, Sanju and Cheng, Kuoyuan and Schäffer, Alejandro A and Aldape, Kenneth and Schiff, Eyal and Ruppin, Eytan

Journal:

Molecular systems biology (2020): e9628

Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection.

Authors:

Kong, Qi and Xiang, Zhiguang and Wu, Yue and Gu, Yu and Guo, Jianguo and Geng, Fei

Journal:

Molecular cancer (2020): 80

Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans and Unique Post-Translational Modifications.

Authors:

Sun, Zeyu and Ren, Keyi and Zhang, Xing and Chen, Jinghua and Jiang, Zhengyi and Jiang, Jing and Ji, Feiyang and Ouyang, Xiaoxi and Li, Lanjuan

Journal:

Engineering (Beijing, China) (2020)

SARS-CoV-2 Infections and ACE2: Clinical Outcomes Linked With Increased Morbidity and Mortality in Individuals With Diabetes.

Authors:

Obukhov, Alexander G and Stevens, Bruce R and Prasad, Ram and Li Calzi, Sergio and Boulton, Michael E and Raizada, Mohan K and Oudit, Gavin Y and Grant, Maria B

Journal:

Diabetes (2020): 1875-1886

Physical properties

Molecular weight	1145.15
Solvent	DMSO

Spectral properties

Correction factor (280 nm)	0.3
Excitation (nm)	322
Emission (nm)	381

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

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Page updated on September 20, 2025