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Mca-YVADAPK(Dnp)-OH
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Mca-YVADAPK(Dnp)-OH is a fluorogenic peptide substrate for detecting caspase-1/interleukin-converting enzyme (ICE) and angiotensin I-converting enzyme-2 (ACE-2). Its N-terminal contains a highly fluorescent 7-methoxycoumarin (MCA) fluorophore that is efficiently quenched by non-fluorescent 2,4-dinitrophenyl group on lysine residue via fluorescence resonance energy transfer (dark FRET). It can be used to measure the activities of caspase-1/interleukin-converting enzyme (ICE) and angiotensin I-converting enzyme-2 (ACE-2) that are capable of cleaving an amide bond between the fluorescent group (MCA) and the quencher group (DNP), resulting an increase in fluorescence.
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References
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Marked Up-Regulation of ACE2 in Hearts of Patients With Obstructive Hypertrophic Cardiomyopathy: Implications for SARS-CoV-2-Mediated COVID-19.
Authors: Bos, J Martijn and Hebl, Virginia B and Oberg, Ann L and Sun, Zhifu and Herman, Daniel S and Teekakirikul, Polakit and Seidman, Jonathan G and Seidman, Christine E and Dos Remedios, Cristobal G and Maleszewski, Joseph J and Schaff, Hartzell V and Dearani, Joseph A and Noseworthy, Peter A and Friedman, Paul A and Ommen, Steve R and Brozovich, Frank V and Ackerman, Michael J
Journal: Mayo Clinic proceedings (2020): 1354-1368
Authors: Bos, J Martijn and Hebl, Virginia B and Oberg, Ann L and Sun, Zhifu and Herman, Daniel S and Teekakirikul, Polakit and Seidman, Jonathan G and Seidman, Christine E and Dos Remedios, Cristobal G and Maleszewski, Joseph J and Schaff, Hartzell V and Dearani, Joseph A and Noseworthy, Peter A and Friedman, Paul A and Ommen, Steve R and Brozovich, Frank V and Ackerman, Michael J
Journal: Mayo Clinic proceedings (2020): 1354-1368
In vitro and in vivo identification of clinically approved drugs that modify ACE2 expression.
Authors: Sinha, Sanju and Cheng, Kuoyuan and Schäffer, Alejandro A and Aldape, Kenneth and Schiff, Eyal and Ruppin, Eytan
Journal: Molecular systems biology (2020): e9628
Authors: Sinha, Sanju and Cheng, Kuoyuan and Schäffer, Alejandro A and Aldape, Kenneth and Schiff, Eyal and Ruppin, Eytan
Journal: Molecular systems biology (2020): e9628
Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection.
Authors: Kong, Qi and Xiang, Zhiguang and Wu, Yue and Gu, Yu and Guo, Jianguo and Geng, Fei
Journal: Molecular cancer (2020): 80
Authors: Kong, Qi and Xiang, Zhiguang and Wu, Yue and Gu, Yu and Guo, Jianguo and Geng, Fei
Journal: Molecular cancer (2020): 80
Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans and Unique Post-Translational Modifications.
Authors: Sun, Zeyu and Ren, Keyi and Zhang, Xing and Chen, Jinghua and Jiang, Zhengyi and Jiang, Jing and Ji, Feiyang and Ouyang, Xiaoxi and Li, Lanjuan
Journal: Engineering (Beijing, China) (2020)
Authors: Sun, Zeyu and Ren, Keyi and Zhang, Xing and Chen, Jinghua and Jiang, Zhengyi and Jiang, Jing and Ji, Feiyang and Ouyang, Xiaoxi and Li, Lanjuan
Journal: Engineering (Beijing, China) (2020)
SARS-CoV-2 Infections and ACE2: Clinical Outcomes Linked With Increased Morbidity and Mortality in Individuals With Diabetes.
Authors: Obukhov, Alexander G and Stevens, Bruce R and Prasad, Ram and Li Calzi, Sergio and Boulton, Michael E and Raizada, Mohan K and Oudit, Gavin Y and Grant, Maria B
Journal: Diabetes (2020): 1875-1886
Authors: Obukhov, Alexander G and Stevens, Bruce R and Prasad, Ram and Li Calzi, Sergio and Boulton, Michael E and Raizada, Mohan K and Oudit, Gavin Y and Grant, Maria B
Journal: Diabetes (2020): 1875-1886