Name: Medetomidine azide
Brand: AAT Bioquest
SKU: 50652
Price: 989 USD
Availability: InStock

Medetomidine azide

Medetomidine azide is an azide-modified α2-adrenergic receptor agonist that enables site-specific bioconjugation via click chemistry while preserving pharmacological activity for creating targeted therapeutics.

Bioorthogonal Conjugation Capability: Azide moiety enables copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC or SPAAC) with alkyne-modified biomolecules
Preserved Receptor Binding: Maintains high affinity for α2-adrenergic receptors with native pharmacological activity post-conjugation
Versatile Applications: Well-suited for targeted delivery, receptor profiling, and chemical probe development in neuropharmacology and molecular imaging
Click Chemistry Compatible: Enables efficient bioorthogonal conjugation reactions

The chemical structure of Medetomidine azide.

Datasheet

SDS

COA

Catalog	Size	Price	Quantity
50652	1 mg	Price

Overview

Medetomidine Azide is a functionalized derivative of medetomidine, a selective α2-adrenergic receptor agonist, modified to incorporate an azide (-N₃) group for bioorthogonal conjugation via copper-catalyzed or copper-free click chemistry. The azide moiety allows for efficient and selective coupling to alkyne-functionalized molecules through Huisgen cycloaddition, enabling covalent attachment under mild conditions without interfering with biological activity. This reagent is ideal for applications requiring spatial and temporal control over conjugation, such as targeted drug delivery, receptor-ligand interaction studies, and the synthesis of functionalized probes or nanoparticles. Medetomidine Azide retains the pharmacological properties of the parent compound, making it a powerful tool for constructing receptor-targeted bioconjugates while preserving biological function.

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Medetomidine azide to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	261.431 µL	1.307 mL	2.614 mL	13.072 mL	26.143 mL
5 mM	52.286 µL	261.431 µL	522.862 µL	2.614 mL	5.229 mL
10 mM	26.143 µL	130.716 µL	261.431 µL	1.307 mL	2.614 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	382.51 g/mol	=	mL	x	mM	=	mmol

References

View all 26 references: Citation Explorer

Dexmedetomidine directly binds to and inhibits Toll-like receptor 4.

Authors:

Koutsogiannaki, Sophia and Limratana, Panop and Bu, Weiming and Maisat, Wiriya and McKinstry-Wu, Andrew and Han, Xiaohui and Ohto, Umeharu and Eckenhoff, Roderic G and Soriano, Sulpicio G and Yuki, Koichi

Journal:

International immunopharmacology (2024): 112975

Evaluation of DNA integrity and chromatin condensation in cat sperm collected by urethral catheterization and epididymis slicing.

Authors:

Allera, Cecilia and Gallelli, María Florencia and Neild, Deborah Margarita and Carretero, María Ignacia

Journal:

Reproduction in domestic animals = Zuchthygiene (2023): 982-989

Evaluation of the effects of two anaesthetic protocols on oxidative status and DNA damage in red-eared sliders (Trachemys scripta elegans) undergoing endoscopic coeliotomy.

Authors:

Došenović, Milan and Radaković, Milena and Vučićević, Miloš and Vejnović, Branislav and Vasiljević, Maja and Marinković, Darko and Stanimirović, Zoran

Journal:

Acta veterinaria Hungarica (2021): 337-344

Cardiac troponin I in dogs anaesthetized with propofol and sevoflurane: the influence of medetomidine premedication and inspired oxygen fraction.

Authors:

Vasiljević, Maja and Krstić, Vanja and Stanković, Sanja and Zrimšek, Petra and Svete, Alenka Nemec and Seliškar, Alenka

Journal:

Veterinary anaesthesia and analgesia (2018): 745-753

Semen quality and interval to sterility in tom cats treated with a 9.4 mg deslorelin implant.

Authors:

Romagnoli, Stefano and Baldan, Anna and Righetti, Camilla and Milani, Chiara and Mollo, Antonio and Stelletta, Calogero

Journal:

Journal of feline medicine and surgery (2017): 194-199

Physical properties

Molecular weight	382.51
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure

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Page updated on April 30, 2026