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Medetomidine azide
Product key features
- Azide moiety enables bioorthogonal conjugation via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC or SPAAC) with a wide range of alkyne-modified biomolecules, including peptides, proteins, polymers, and nanomaterials.
- Maintains high affinity for α2-adrenergic receptors preserving native pharmacological activity post-conjugation.
- Well-suited for targeted delivery, receptor profiling, and chemical probe development in neuropharmacology and molecular imaging.
Product description
Medetomidine Azide is a functionalized derivative of medetomidine, a selective α2-adrenergic receptor agonist, modified to incorporate an azide (-N₃) group for bioorthogonal conjugation via copper-catalyzed or copper-free click chemistry. The azide moiety allows for efficient and selective coupling to alkyne-functionalized molecules through Huisgen cycloaddition, enabling covalent attachment under mild conditions without interfering with biological activity. This reagent is ideal for applications requiring spatial and temporal control over conjugation, such as targeted drug delivery, receptor-ligand interaction studies, and the synthesis of functionalized probes or nanoparticles. Medetomidine Azide retains the pharmacological properties of the parent compound, making it a powerful tool for constructing receptor-targeted bioconjugates while preserving biological function.
References
View all 26 references: Citation Explorer
Dexmedetomidine directly binds to and inhibits Toll-like receptor 4.
Authors: Koutsogiannaki, Sophia and Limratana, Panop and Bu, Weiming and Maisat, Wiriya and McKinstry-Wu, Andrew and Han, Xiaohui and Ohto, Umeharu and Eckenhoff, Roderic G and Soriano, Sulpicio G and Yuki, Koichi
Journal: International immunopharmacology (2024): 112975
Authors: Koutsogiannaki, Sophia and Limratana, Panop and Bu, Weiming and Maisat, Wiriya and McKinstry-Wu, Andrew and Han, Xiaohui and Ohto, Umeharu and Eckenhoff, Roderic G and Soriano, Sulpicio G and Yuki, Koichi
Journal: International immunopharmacology (2024): 112975
Evaluation of DNA integrity and chromatin condensation in cat sperm collected by urethral catheterization and epididymis slicing.
Authors: Allera, Cecilia and Gallelli, María Florencia and Neild, Deborah Margarita and Carretero, María Ignacia
Journal: Reproduction in domestic animals = Zuchthygiene (2023): 982-989
Authors: Allera, Cecilia and Gallelli, María Florencia and Neild, Deborah Margarita and Carretero, María Ignacia
Journal: Reproduction in domestic animals = Zuchthygiene (2023): 982-989
Evaluation of the effects of two anaesthetic protocols on oxidative status and DNA damage in red-eared sliders (Trachemys scripta elegans) undergoing endoscopic coeliotomy.
Authors: Došenović, Milan and Radaković, Milena and Vučićević, Miloš and Vejnović, Branislav and Vasiljević, Maja and Marinković, Darko and Stanimirović, Zoran
Journal: Acta veterinaria Hungarica (2021): 337-344
Authors: Došenović, Milan and Radaković, Milena and Vučićević, Miloš and Vejnović, Branislav and Vasiljević, Maja and Marinković, Darko and Stanimirović, Zoran
Journal: Acta veterinaria Hungarica (2021): 337-344
Cardiac troponin I in dogs anaesthetized with propofol and sevoflurane: the influence of medetomidine premedication and inspired oxygen fraction.
Authors: Vasiljević, Maja and Krstić, Vanja and Stanković, Sanja and Zrimšek, Petra and Svete, Alenka Nemec and Seliškar, Alenka
Journal: Veterinary anaesthesia and analgesia (2018): 745-753
Authors: Vasiljević, Maja and Krstić, Vanja and Stanković, Sanja and Zrimšek, Petra and Svete, Alenka Nemec and Seliškar, Alenka
Journal: Veterinary anaesthesia and analgesia (2018): 745-753
Semen quality and interval to sterility in tom cats treated with a 9.4 mg deslorelin implant.
Authors: Romagnoli, Stefano and Baldan, Anna and Righetti, Camilla and Milani, Chiara and Mollo, Antonio and Stelletta, Calogero
Journal: Journal of feline medicine and surgery (2017): 194-199
Authors: Romagnoli, Stefano and Baldan, Anna and Righetti, Camilla and Milani, Chiara and Mollo, Antonio and Stelletta, Calogero
Journal: Journal of feline medicine and surgery (2017): 194-199
Page updated on June 29, 2025
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