Name: Medetomidine NHS Ester
Brand: AAT Bioquest
SKU: 50650
Price: 989 USD
Availability: InStock

Medetomidine NHS Ester

Medetomidine NHS ester is an amine-reactive α2-adrenergic agonist that forms stable amide bonds with primary amines, preserving pharmacological activity for creating medetomidine-based bioconjugates and sensors.

Amine-Reactive NHS ester: Enables efficient, site-specific conjugation to primary amines under mild, aqueous conditions (pH 7.2–8.5)
Retains Pharmacological Activity: Preserves the α2-adrenergic receptor agonist function of medetomidine for use in receptor-targeting applications
Optimized for Biofunctional Applications: Useful in receptor-binding assays, targeted drug delivery, biosensor development, and imaging probe synthesis
Stable Amide Bond Formation: Creates robust conjugates suitable for long-term biological studies

The chemical structure of Medetomidine NHS ester.

Datasheet

SDS

COA

Catalog	Size	Price	Quantity
50650	1 mg	Price

Overview

Medetomidine NHS Ester is an amine-reactive derivative of medetomidine, a potent alpha-2 adrenergic receptor agonist. This compound incorporates an N-hydroxysuccinimide (NHS) ester group, enabling efficient and selective conjugation to primary amines under mild, aqueous conditions (typically pH 7.2–8.5). The resulting amide bond is stable, making this reagent well-suited for covalently attaching medetomidine to peptides, proteins, or other biomolecules. Medetomidine NHS Ester retains the pharmacological activity of the parent compound, allowing it to be used in targeted drug delivery, receptor-ligand interaction studies, and biosensor development. Its versatility also makes it valuable for functionalizing surfaces or creating tracer-labeled conjugates for imaging and detection purposes. This reagent is particularly useful in applications where site-specific coupling and receptor targeting are required.

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Medetomidine NHS Ester to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	243.013 µL	1.215 mL	2.43 mL	12.151 mL	24.301 mL
5 mM	48.603 µL	243.013 µL	486.027 µL	2.43 mL	4.86 mL
10 mM	24.301 µL	121.507 µL	243.013 µL	1.215 mL	2.43 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	411.5 g/mol	=	mL	x	mM	=	mmol

References

View all 50 references: Citation Explorer

A RETROSPECTIVE STUDY COMPARING THE SAFETY OF KETAMINE-MEDETOMIDINE AND TILETAMINE-ZOLAZEPAM-MEDETOMIDINE FOR CHEMICAL RESTRAINT OF CAPTIVE PANTHERA SPP.

Authors:

Norman B, Alexander and Simpson-Brown, Elliott and Patterson B, Stuart

Journal:

Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians (2025): 16-24

Accidental coadministration of medetomidine, vatinoxan and ketamine in a cat.

Authors:

Koura, Maria and Koliou, Eleni and Kourmpeti, Stavroula and Kazakos, Georgios

Journal:

Veterinary anaesthesia and analgesia (2025)

Effects of hydromorphone alone and combined with medetomidine-vatinoxan or dexmedetomidine on alfaxalone induction dose and mean arterial pressure in dogs anesthetized with sevoflurane.

Authors:

Davis, Lily V and Hampton, Chiara E and Kleine, Stephanie A and Smith, Christopher K and Bussières, Genevieve and Zhu, Xiaojuan and Seddighi, Reza

Journal:

Veterinary anaesthesia and analgesia (2025): 43-52

Intranasal administration and intramuscular administration of medetomidine are effective for sedation and may increase cardiac size in cats.

Authors:

Kaya, Zehranur and Yanmaz, Latif Emrah

Journal:

Journal of the American Veterinary Medical Association (2025): 599-603

Comparison of intramuscular medetomidine versus medetomidine-vatinoxan sedation in bearded dragons (Pogonavitticeps).

Authors:

Pinho, Renata H and Reed, Maya and Chapman, Kelsey and Pang, Daniel Sj

Journal:

Veterinary anaesthesia and analgesia (2025): 72-77

Physical properties

Molecular weight	411.50
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure

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Page updated on May 8, 2026