Medetomidine NHS Ester
Product key features
- Amine-reactive NHS ester – Enables efficient, site-specific conjugation to primary amines under mild, aqueous conditions (pH 7.2–8.5).
- Retains pharmacological activity – Preserves the α2-adrenergic receptor agonist function of medetomidine for use in receptor-targeting applications.
- Optimized for biofunctional applications – Useful in receptor-binding assays, targeted drug delivery, biosensor development, and imaging probe synthesis.
Product description
Medetomidine NHS Ester is an amine-reactive derivative of medetomidine, a potent alpha-2 adrenergic receptor agonist. This compound incorporates an N-hydroxysuccinimide (NHS) ester group, enabling efficient and selective conjugation to primary amines under mild, aqueous conditions (typically pH 7.2–8.5). The resulting amide bond is stable, making this reagent well-suited for covalently attaching medetomidine to peptides, proteins, or other biomolecules. Medetomidine NHS Ester retains the pharmacological activity of the parent compound, allowing it to be used in targeted drug delivery, receptor-ligand interaction studies, and biosensor development. Its versatility also makes it valuable for functionalizing surfaces or creating tracer-labeled conjugates for imaging and detection purposes. This reagent is particularly useful in applications where site-specific coupling and receptor targeting are required.
Product family
Name | Excitation (nm) | Emission (nm) | Extinction coefficient (cm -1 M -1) | Quantum yield | Correction Factor (260 nm) | Correction Factor (280 nm) |
Cy2DIGE NHS ester | 492 | 508 | 150000 | 0.120 | 0.08 | 0.15 |
Cy3B NHS ester | 560 | 571 | 1200001 | 0.581 | 0.048 | 0.069 |
Cy3DIGE NHS ester | 555 | 569 | 1500001 | 0.151 | 0.07 | 0.073 |
Cy5DIGE NHS ester | 651 | 670 | 2500001 | 0.271, 0.42 | 0.02 | 0.03 |
CypHer5E NHS Ester | 643 | 660 | - | - | - | - |
CypHer7E NHS Ester | 748 | 769 | - | - | - | - |
QXY21 NHS ester [equivalent to QSY-21 NHS ester] | - | - | 890001 | - | - | 0.32 |
QXY7 NHS ester [equivalent to QSY-7 NHS ester] | - | - | 900001 | - | - | 0.22 |
XFD350 NHS Ester *Same Structure to Alexa Fluor™ 350 NHS Ester* | 343 | 441 | 19000 | - | 0.25 | 0.19 |
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References
View all 50 references: Citation Explorer
A RETROSPECTIVE STUDY COMPARING THE SAFETY OF KETAMINE-MEDETOMIDINE AND TILETAMINE-ZOLAZEPAM-MEDETOMIDINE FOR CHEMICAL RESTRAINT OF CAPTIVE PANTHERA SPP.
Authors: Norman B, Alexander and Simpson-Brown, Elliott and Patterson B, Stuart
Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians (2025): 16-24
Authors: Norman B, Alexander and Simpson-Brown, Elliott and Patterson B, Stuart
Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians (2025): 16-24
Accidental coadministration of medetomidine, vatinoxan and ketamine in a cat.
Authors: Koura, Maria and Koliou, Eleni and Kourmpeti, Stavroula and Kazakos, Georgios
Journal: Veterinary anaesthesia and analgesia (2025)
Authors: Koura, Maria and Koliou, Eleni and Kourmpeti, Stavroula and Kazakos, Georgios
Journal: Veterinary anaesthesia and analgesia (2025)
Effects of hydromorphone alone and combined with medetomidine-vatinoxan or dexmedetomidine on alfaxalone induction dose and mean arterial pressure in dogs anesthetized with sevoflurane.
Authors: Davis, Lily V and Hampton, Chiara E and Kleine, Stephanie A and Smith, Christopher K and Bussières, Genevieve and Zhu, Xiaojuan and Seddighi, Reza
Journal: Veterinary anaesthesia and analgesia (2025): 43-52
Authors: Davis, Lily V and Hampton, Chiara E and Kleine, Stephanie A and Smith, Christopher K and Bussières, Genevieve and Zhu, Xiaojuan and Seddighi, Reza
Journal: Veterinary anaesthesia and analgesia (2025): 43-52
Intranasal administration and intramuscular administration of medetomidine are effective for sedation and may increase cardiac size in cats.
Authors: Kaya, Zehranur and Yanmaz, Latif Emrah
Journal: Journal of the American Veterinary Medical Association (2025): 599-603
Authors: Kaya, Zehranur and Yanmaz, Latif Emrah
Journal: Journal of the American Veterinary Medical Association (2025): 599-603
Comparison of intramuscular medetomidine versus medetomidine-vatinoxan sedation in bearded dragons (Pogonavitticeps).
Authors: Pinho, Renata H and Reed, Maya and Chapman, Kelsey and Pang, Daniel Sj
Journal: Veterinary anaesthesia and analgesia (2025): 72-77
Authors: Pinho, Renata H and Reed, Maya and Chapman, Kelsey and Pang, Daniel Sj
Journal: Veterinary anaesthesia and analgesia (2025): 72-77
Page updated on June 30, 2025