Medetomidine NHS Ester

Product key features

Amine-reactive NHS ester – Enables efficient, site-specific conjugation to primary amines under mild, aqueous conditions (pH 7.2–8.5).
Retains pharmacological activity – Preserves the α2-adrenergic receptor agonist function of medetomidine for use in receptor-targeting applications.
Optimized for biofunctional applications – Useful in receptor-binding assays, targeted drug delivery, biosensor development, and imaging probe synthesis.

Product description

Medetomidine NHS Ester is an amine-reactive derivative of medetomidine, a potent alpha-2 adrenergic receptor agonist. This compound incorporates an N-hydroxysuccinimide (NHS) ester group, enabling efficient and selective conjugation to primary amines under mild, aqueous conditions (typically pH 7.2–8.5). The resulting amide bond is stable, making this reagent well-suited for covalently attaching medetomidine to peptides, proteins, or other biomolecules. Medetomidine NHS Ester retains the pharmacological activity of the parent compound, allowing it to be used in targeted drug delivery, receptor-ligand interaction studies, and biosensor development. Its versatility also makes it valuable for functionalizing surfaces or creating tracer-labeled conjugates for imaging and detection purposes. This reagent is particularly useful in applications where site-specific coupling and receptor targeting are required.

Product family

Name	Excitation (nm)	Emission (nm)	Extinction coefficient (cm ^-1 M ^-1)	Quantum yield	Correction Factor (260 nm)	Correction Factor (280 nm)
Cy2DIGE NHS ester	492	508	150000	0.120	0.08	0.15
Cy3B NHS ester	560	571	120000¹	0.58¹	0.048	0.069
Cy3DIGE NHS ester	555	569	150000¹	0.15¹	0.07	0.073
Cy5DIGE NHS ester	651	670	250000¹	0.27¹, 0.4²	0.02	0.03
CypHer5E NHS Ester	643	660	-	-	-	-
CypHer7E NHS Ester	748	769	-	-	-	-
QXY21 NHS ester [equivalent to QSY-21 NHS ester]	-	-	89000¹	-	-	0.32
QXY7 NHS ester [equivalent to QSY-7 NHS ester]	-	-	90000¹	-	-	0.22
XFD350 NHS Ester Same Structure to Alexa Fluor™ 350 NHS Ester	343	441	19000	-	0.25	0.19
XFD430 NHS ester	432	540	15,000	-	-	0.28
XFD488 NHS Ester Same Structure to Alexa Fluor™ 488 NHS Ester	499	520	71000	0.92¹	0.30	0.11
XFD514 NHS Ester Same Structure to Alexa Fluor™ 514 NHS Ester	518	543	80000	-	0.31	0.18
XFD532 NHS Ester Same Structure to Alexa Fluor™ 532 NHS Ester	534	553	81000	0.61¹	0.24	0.09
XFD546 NHS Ester Same Structure to Alexa Fluor™ 546 NHS Ester	561	572	112000	0.79¹	0.21	0.12
XFD555 NHS Ester Same Structure to Alexa Fluor™ 555 NHS Ester	553	568	150000	0.1¹	0.08	0.08
XFD568 NHS Ester Same Structure to Alexa Fluor™ 568 NHS Ester	579	603	91300	0.69¹	0.45	0.46
XFD594 NHS Ester Same Structure to Alexa Fluor™ 594 NHS Ester	590	618	90000	0.66¹	0.43	0.56
XFD647 NHS Ester Same Structure to Alexa Fluor™ 647 NHS Ester	650	671	239000	0.33¹	0.00	0.03
XFD660 NHS Ester [equivalent to Alexa Fluor® 660 NHS Ester]	663	691	132000	-	0.00	0.10
XFD680 NHS Ester Same Structure to Alexa Fluor™ 680 NHS Ester	681	704	184000	0.36¹	0.00	0.05
XFD700 NHS Ester Same Structure to Alexa Fluor™ 700 NHS Ester	696	719	192000	0.25¹	0.00	0.07
XFD750 NHS Ester Same Structure to Alexa Fluor™ 750 NHS Ester	752	776	240000	0.12¹	0.00	0.04
XFD790 NHS Ester	782	805	260,000	-	0.09	0.08
Show More (14)

References

View all 50 references: Citation Explorer

A RETROSPECTIVE STUDY COMPARING THE SAFETY OF KETAMINE-MEDETOMIDINE AND TILETAMINE-ZOLAZEPAM-MEDETOMIDINE FOR CHEMICAL RESTRAINT OF CAPTIVE PANTHERA SPP.
Authors: Norman B, Alexander and Simpson-Brown, Elliott and Patterson B, Stuart
Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians (2025): 16-24

Accidental coadministration of medetomidine, vatinoxan and ketamine in a cat.
Authors: Koura, Maria and Koliou, Eleni and Kourmpeti, Stavroula and Kazakos, Georgios
Journal: Veterinary anaesthesia and analgesia (2025)

Effects of hydromorphone alone and combined with medetomidine-vatinoxan or dexmedetomidine on alfaxalone induction dose and mean arterial pressure in dogs anesthetized with sevoflurane.
Authors: Davis, Lily V and Hampton, Chiara E and Kleine, Stephanie A and Smith, Christopher K and Bussières, Genevieve and Zhu, Xiaojuan and Seddighi, Reza
Journal: Veterinary anaesthesia and analgesia (2025): 43-52

Intranasal administration and intramuscular administration of medetomidine are effective for sedation and may increase cardiac size in cats.
Authors: Kaya, Zehranur and Yanmaz, Latif Emrah
Journal: Journal of the American Veterinary Medical Association (2025): 599-603

Comparison of intramuscular medetomidine versus medetomidine-vatinoxan sedation in bearded dragons (Pogonavitticeps).
Authors: Pinho, Renata H and Reed, Maya and Chapman, Kelsey and Pang, Daniel Sj
Journal: Veterinary anaesthesia and analgesia (2025): 72-77

Page updated on July 25, 2025

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