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Medetomidine NHS Ester

Product key features

  • Amine-reactive NHS ester – Enables efficient, site-specific conjugation to primary amines under mild, aqueous conditions (pH 7.2–8.5).
  • Retains pharmacological activity – Preserves the α2-adrenergic receptor agonist function of medetomidine for use in receptor-targeting applications.
  • Optimized for biofunctional applications – Useful in receptor-binding assays, targeted drug delivery, biosensor development, and imaging probe synthesis.

Product description

Medetomidine NHS Ester is an amine-reactive derivative of medetomidine, a potent alpha-2 adrenergic receptor agonist. This compound incorporates an N-hydroxysuccinimide (NHS) ester group, enabling efficient and selective conjugation to primary amines under mild, aqueous conditions (typically pH 7.2–8.5). The resulting amide bond is stable, making this reagent well-suited for covalently attaching medetomidine to peptides, proteins, or other biomolecules. Medetomidine NHS Ester retains the pharmacological activity of the parent compound, allowing it to be used in targeted drug delivery, receptor-ligand interaction studies, and biosensor development. Its versatility also makes it valuable for functionalizing surfaces or creating tracer-labeled conjugates for imaging and detection purposes. This reagent is particularly useful in applications where site-specific coupling and receptor targeting are required.

Product family

NameExcitation (nm)Emission (nm)Extinction coefficient (cm -1 M -1)Quantum yieldCorrection Factor (260 nm)Correction Factor (280 nm)
Cy2DIGE NHS ester4925081500000.1200.080.15
Cy3B NHS ester56057112000010.5810.0480.069
Cy3DIGE NHS ester55556915000010.1510.070.073
Cy5DIGE NHS ester65167025000010.271, 0.420.020.03
CypHer5E NHS Ester643660----
CypHer7E NHS Ester748769----
QXY21 NHS ester [equivalent to QSY-21 NHS ester]--890001--0.32
QXY7 NHS ester [equivalent to QSY-7 NHS ester]--900001--0.22
XFD350 NHS Ester *Same Structure to Alexa Fluor™ 350 NHS Ester*34344119000-0.250.19
XFD430 NHS ester43254015,000--0.28
XFD488 NHS Ester *Same Structure to Alexa Fluor™ 488 NHS Ester*499520710000.9210.300.11
XFD514 NHS Ester *Same Structure to Alexa Fluor™ 514 NHS Ester*51854380000-0.310.18
XFD532 NHS Ester *Same Structure to Alexa Fluor™ 532 NHS Ester*534553810000.6110.240.09
XFD546 NHS Ester *Same Structure to Alexa Fluor™ 546 NHS Ester*5615721120000.7910.210.12
XFD555 NHS Ester *Same Structure to Alexa Fluor™ 555 NHS Ester*5535681500000.110.080.08
XFD568 NHS Ester *Same Structure to Alexa Fluor™ 568 NHS Ester*579603913000.6910.450.46
XFD594 NHS Ester *Same Structure to Alexa Fluor™ 594 NHS Ester*590618900000.6610.430.56
XFD647 NHS Ester *Same Structure to Alexa Fluor™ 647 NHS Ester*6506712390000.3310.000.03
XFD660 NHS Ester [equivalent to Alexa Fluor® 660 NHS Ester]663691132000-0.000.10
XFD680 NHS Ester *Same Structure to Alexa Fluor™ 680 NHS Ester*6817041840000.3610.000.05
XFD700 NHS Ester *Same Structure to Alexa Fluor™ 700 NHS Ester*6967191920000.2510.000.07
XFD750 NHS Ester *Same Structure to Alexa Fluor™ 750 NHS Ester*7527762400000.1210.000.04
XFD790 NHS Ester782805260,000-0.090.08
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References

View all 50 references: Citation Explorer
A RETROSPECTIVE STUDY COMPARING THE SAFETY OF KETAMINE-MEDETOMIDINE AND TILETAMINE-ZOLAZEPAM-MEDETOMIDINE FOR CHEMICAL RESTRAINT OF CAPTIVE PANTHERA SPP.
Authors: Norman B, Alexander and Simpson-Brown, Elliott and Patterson B, Stuart
Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians (2025): 16-24
Accidental coadministration of medetomidine, vatinoxan and ketamine in a cat.
Authors: Koura, Maria and Koliou, Eleni and Kourmpeti, Stavroula and Kazakos, Georgios
Journal: Veterinary anaesthesia and analgesia (2025)
Effects of hydromorphone alone and combined with medetomidine-vatinoxan or dexmedetomidine on alfaxalone induction dose and mean arterial pressure in dogs anesthetized with sevoflurane.
Authors: Davis, Lily V and Hampton, Chiara E and Kleine, Stephanie A and Smith, Christopher K and Bussières, Genevieve and Zhu, Xiaojuan and Seddighi, Reza
Journal: Veterinary anaesthesia and analgesia (2025): 43-52
Intranasal administration and intramuscular administration of medetomidine are effective for sedation and may increase cardiac size in cats.
Authors: Kaya, Zehranur and Yanmaz, Latif Emrah
Journal: Journal of the American Veterinary Medical Association (2025): 599-603
Comparison of intramuscular medetomidine versus medetomidine-vatinoxan sedation in bearded dragons (Pogonavitticeps).
Authors: Pinho, Renata H and Reed, Maya and Chapman, Kelsey and Pang, Daniel Sj
Journal: Veterinary anaesthesia and analgesia (2025): 72-77
Page updated on June 30, 2025

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Catalog Number50650
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Physical properties

Molecular weight

411.50

Solvent

DMSO

Storage, safety and handling

H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22

Storage

Freeze (< -15 °C); Minimize light exposure
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