MitoDNA™ Red 610

MitoDNA™ Red 610 is a red-emitting probe that preferentially stains mitochondrial DNA over nuclear DNA, providing specific mtDNA detection for studying mitochondrial genetics and dysfunction.

mtDNA-Specific: Selectively binds to mtDNA without nuclear interference
Live-Cell Compatibility: Easily permeates cells for real-time mtDNA tracking
High Signal Clarity: Large Stokes shift ensures a strong signal-to-noise ratio for multiplex imaging
Broad Research Applicability: Ideal for investigating mtDNA-linked diseases and mitochondrial function

The fluorescence response of MitoDNA™ Red 610 (5 µM) in HeLa cells was assessed before and after DNase treatment. Fluorescence intensities were monitored using fluorescence microscopy.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
22687	1 mg	Price

Overview

There are very few probes that can be effectively used to detect mitochondrial deoxyribonucleic acid (mtDNA). The common fluorescent DNA probes (such as DAPI, Hoechst or SYBR® Green) lack the specificity to target mitochondria. They predominantly stain nuclei. MitoDNA™ Red 610 is a cell permeable dye that specifically stains mtDNA in live cells. It provides an efficient way of labeling mtDNA for the dynamic imaging of mtDNA in live cells. MitoDNA™ Red 610 has a large Stokes Shift that gives great signal-to-noise ratio and can be easily used for multiplex staining in cells with other fluorescent imaging probes. mtDNA is a small circular DNA found within mitochondria present in the cytoplasm of a cell. This DNA is supplementary to the nucleic acid material found in the nucleus of each cell. The mtDNA codes for 37 genes that promote the proper functioning of some cells. The mitochondria synthesize adenosine triphosphate (ATP) through oxidative phosphorylation and encode information for the synthesis of enzymes, transfer ribonucleic acid (tRNA), and ribosomal RNA (rRNA). Disorders of mtDNA and mutations in its genes can predispose to health problems like age-related hearing loss, diabetes, and brain, heart, and liver failure, among other conditions. Moreover, mtDNA and its associated mitochondrial disorders can predispose people to different types of cancers including lymphomas, leukemias, and breast, intestine, liver and kidney tumors etc.

References

View all 50 references: Citation Explorer

A prognostic model of idiopathic pulmonary fibrosis constructed based on macrophage and mitochondria-related genes.

Authors:

Bao, Yu and Yang, Shiyuan and Zhao, Hailan and Wang, Yezhen and Li, Ke and Liu, Xue and Zhang, Wei and Zhu, Xue

Journal:

BMC pulmonary medicine (2024): 176

MSC-derived mitochondria promote axonal regeneration via Atf3 gene up-regulation by ROS induced DNA double strand breaks at transcription initiation region.

Authors:

Zhang, Yingchi and Xu, Tao and Xie, Jie and Wu, Hua and Hu, Weihua and Yuan, Xuefeng

Journal:

Cell communication and signaling : CCS (2024): 240

Mitochondria function in cytoplasmic FeS protein biogenesis.

Authors:

Dancis, Andrew and Pandey, Ashutosh K and Pain, Debkumar

Journal:

Biochimica et biophysica acta. Molecular cell research (2024): 119733

Mitochondria transcription and cancer.

Authors:

Lei, Tang and Rui, Yu and Xiaoshuang, Zhou and Jinglan, Zhang and Jihong, Zhang

Journal:

Cell death discovery (2024): 168

Mitochondria-mediated Ferroptosis in Diseases Therapy: From Molecular Mechanisms to Implications.

Authors:

Feng, Fuhai and He, Shasha and Li, Xiaoling and He, Jiake and Luo, Lianxiang

Journal:

Aging and disease (2024): 714-738

Physical properties

Molecular weight	344.93
Solvent	DMSO

Spectral properties

Excitation (nm)	508
Emission (nm)	607

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure

Instrument settings

Fluorescence microscope
Excitation	490 nm
Emission	610 nm
Recommended plate	Black wall/clear bottom

Documents

Protocol
Safety Data Sheet
Certificate of Analysis

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Page updated on October 22, 2025