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MitoLite™ NIR FX690
Mitochondria are membrane-enclosed organelles found in most eukaryotic cells. Mitochondria generate most of the cellular supply of ATP. In addition to supplying cellular energy, mitochondria are involved in a range of other processes, such as signaling, cellular differentiation, cell death, as well as the control of the cell cycle and cell growth. Mitochondria have been implicated in several human diseases, including mitochondrial disorders and cardiac dysfunction, and may play a role in the aging process. Mitolite™ NIR FX690 is designed to label mitochondria in live cells with near infrared fluorescence. It selectively accumulates in mitochondria probably via the mitochondrial membrane potential gradient. It is an ideal choice for imaging live cells and tissues where low background, and high signal-to-noise ratio is critical. This fluorescent mitochondrial indicator is retained in mitochondria for a long time since it carries a cell-retaining group. This key feature significantly increases the staining efficiency. It is useful for a variety of studies, including cell adhesion, chemotaxis, multidrug resistance, cell viability, apoptosis and cytotoxicity.
<p>Fluorescence images of HeLa cells stained with MitoLite&trade; NIR FX690 using fluorescence microscope with a Cy5 filter set (Red). After fixation, the cells were labeled with F-actin dye iFluor® 488-Phalloidin (Cat#23115, Green) and counterstained with Nuclear Blue&trade; DCS1 (Cat#17548, Blue).</p>
<p>Fluorescence images of HeLa cells stained with MitoLite&trade; NIR FX690 using fluorescence microscope with a Cy5 filter set (Red). After fixation, the cells were labeled with F-actin dye iFluor® 488-Phalloidin (Cat#23115, Green) and counterstained with Nuclear Blue&trade; DCS1 (Cat#17548, Blue).</p>
protocol
Protocol
sds
SDS
COA
CatalogSize
Price
Quantity
22690500 Tests
Price
 
Physical properties
Molecular weightN/A
SolventDMSO
Spectral properties
Excitation (nm)658
Emission (nm)691
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
UNSPSC12352200
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Page updated on October 8, 2025