Name: MM(PEG)24 Methyl-PEG-Maleimide Reagent
Brand: AAT Bioquest
SKU: 4525
Price: 115 USD
Availability: InStock

MM(PEG)24 Methyl-PEG-Maleimide Reagent

MM(PEG)24 is a methyl-terminated, polyethylene glycol compound (24 PEG units) activated with a maleimide group for covalent pegylation of sulfhydryls on biomolecules or assay surfaces. MM(PEG)24 is used for efficient PEGylation of sulfhydryl groups at pH 6.5-7.5. It has fully characterized and defined PEG chain lengths with discrete molecular weight for consistency of performance in protein-modification applications. Its PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity. This PEG reagent has been used for PEGylating assay surfaces, adding inert mass to proteins, immunogens, drug compounds and probes, improving solubility (decrease aggregation) of proteins or peptides without affecting function, and protecting proteins from proteolysis.PEG-containing reagents have been used to modify proteins to provide specific advantages. Protein PEGylation can improve the stability of the modified protein, protect it from proteolytic digestion, increase its half life in biological applications, mask it from causing an immunogenic response, decrease its antigenicity or potential toxicity, improve its solubility, diminish the potential for aggregation, and minimize interference for both in vitro and in vivo applications.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
4525	25 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of Water needed to reconstitute specific mass of MM(PEG)24 Methyl-PEG-Maleimide Reagent to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	80.681 µL	403.405 µL	806.809 µL	4.034 mL	8.068 mL
5 mM	16.136 µL	80.681 µL	161.362 µL	806.809 µL	1.614 mL
10 mM	8.068 µL	40.34 µL	80.681 µL	403.405 µL	806.809 µL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	1239.45 g/mol	=	mL	x	mM	=	mmol

Citations

View all 8 citations: Citation Explorer

H 2 O 2-Mediated Oxidative Stress Enhances Cystathionine $\gamma$-Lyase-Derived H 2 S Synthesis via a Sulfenic Acid Intermediate

Authors:

Li, Heng and Yan, Shasha and Qian, Jing and Guo, Xin and Li, Ge and Qi, Haizhen and Zhu, Zhilong and Wu, Yanjun and He, Weijuan

Journal:

Antioxidants (2021): 1488

H2O2-Mediated Oxidative Stress Enhances Cystathionine $\gamma$-Lyase-Derived H2S Synthesis via a Sulfenic Acid Intermediate

Authors:

Wang, Jun and Jia, Guanya and Li, Heng and Yan, Shasha and Qian, Jing and Guo, Xin and Li, Ge and Qi, Haizhen and Zhu, Zhilong and Wu, Yanjun and others,

Journal:

Antioxidants (2021): 1488

Loss of PEG chain in routine SDS-PAGE analysis of PEG-maleimide modified protein

Authors:

Zhang, C., Liu, Y., Feng, C., Wang, Q., Shi, H., Zhao, D., Yu, R., Su, Z.

Journal:

Electrophoresis (2015): 371-4

Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes

Authors:

Gutowski, S. M., Shoemaker, J. T., Templeman, K. L., Wei, Y., Latour, R. A., Jr., Bellamkonda, R. V., LaPlaca, M. C., Garcia, A. J.

Journal:

Biomaterials (2015): 55-70

Quantification of PEG-maleimide ligands and coupling efficiencies on nanoparticles with Ellman's reagent

Authors:

Moser, M., Behnke, T., Hamers-Allin, C., Klein-Hartwig, K., Falkenhagen, J., Resch-Genger, U.

Journal:

Anal Chem (2015): 9376-83

Physical properties

Molecular weight	1239.45
Solvent	Water

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C)
UNSPSC	12352200
CAS	88504-24-9

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Page updated on October 12, 2025