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MM(PEG)24 Methyl-PEG-Maleimide Reagent

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Physical properties
Molecular weight1239.45
SolventWater
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C)
UNSPSC12352200

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CAS
88504-24-9
Molecular weight
1239.45
MM(PEG)24 is a methyl-terminated, polyethylene glycol compound (24 PEG units) activated with a maleimide group for covalent pegylation of sulfhydryls on biomolecules or assay surfaces. MM(PEG)24 is used for efficient PEGylation of sulfhydryl groups at pH 6.5-7.5. It has fully characterized and defined PEG chain lengths with discrete molecular weight for consistency of performance in protein-modification applications. Its PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity. This PEG reagent has been used for PEGylating assay surfaces, adding inert mass to proteins, immunogens, drug compounds and probes, improving solubility (decrease aggregation) of proteins or peptides without affecting function, and protecting proteins from proteolysis.PEG-containing reagents have been used to modify proteins to provide specific advantages. Protein PEGylation can improve the stability of the modified protein, protect it from proteolytic digestion, increase its half life in biological applications, mask it from causing an immunogenic response, decrease its antigenicity or potential toxicity, improve its solubility, diminish the potential for aggregation, and minimize interference for both in vitro and in vivo applications.

Calculators


Common stock solution preparation

Table 1. Volume of Water needed to reconstitute specific mass of MM(PEG)24 Methyl-PEG-Maleimide Reagent to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM80.681 µL403.405 µL806.809 µL4.034 mL8.068 mL
5 mM16.136 µL80.681 µL161.362 µL806.809 µL1.614 mL
10 mM8.068 µL40.34 µL80.681 µL403.405 µL806.809 µL

Molarity calculator

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Citations


View all 8 citations: Citation Explorer
H 2 O 2-Mediated Oxidative Stress Enhances Cystathionine $\gamma$-Lyase-Derived H 2 S Synthesis via a Sulfenic Acid Intermediate
Authors: Li, Heng and Yan, Shasha and Qian, Jing and Guo, Xin and Li, Ge and Qi, Haizhen and Zhu, Zhilong and Wu, Yanjun and He, Weijuan
Journal: Antioxidants (2021): 1488
H2O2-Mediated Oxidative Stress Enhances Cystathionine $\gamma$-Lyase-Derived H2S Synthesis via a Sulfenic Acid Intermediate
Authors: Wang, Jun and Jia, Guanya and Li, Heng and Yan, Shasha and Qian, Jing and Guo, Xin and Li, Ge and Qi, Haizhen and Zhu, Zhilong and Wu, Yanjun and others,
Journal: Antioxidants (2021): 1488
Quantification of PEG-maleimide ligands and coupling efficiencies on nanoparticles with Ellman&apos;s reagent
Authors: Moser, M., Behnke, T., Hamers-Allin, C., Klein-Hartwig, K., Falkenhagen, J., Resch-Genger, U.
Journal: Anal Chem (2015): 9376-83
Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes
Authors: Gutowski, S. M., Shoemaker, J. T., Templeman, K. L., Wei, Y., Latour, R. A., Jr., Bellamkonda, R. V., LaPlaca, M. C., Garcia, A. J.
Journal: Biomaterials (2015): 55-70
Loss of PEG chain in routine SDS-PAGE analysis of PEG-maleimide modified protein
Authors: Zhang, C., Liu, Y., Feng, C., Wang, Q., Shi, H., Zhao, D., Yu, R., Su, Z.
Journal: Electrophoresis (2015): 371-4
PEG-maleimide hydrogels for protein and cell delivery in regenerative medicine
Authors: Garcia, A. J.
Journal: Ann Biomed Eng (2014): 312-22
Rapidly in situ forming adhesive hydrogel based on a PEG-maleimide modified polypeptide through Michael addition
Authors: Zhou, Y., Nie, W., Zhao, J., Yuan, X.
Journal: J Mater Sci Mater Med (2013): 2277-86
N-glycan targeted gene delivery to the dendritic cell SIGN receptor
Authors: Anderson, Kevin and Fern, undefined and ez, Christian and Rice, Kevin G
Journal: Bioconjugate chemistry (2010): 1479--1485