Mouse Anti-PEG mAb [Anti-Polyethylene glycol monoclonal antibody]

Beyond hydrophilic polymers in amphiphilic polymer-based self-assembled NanoCarriers: Small hydrophilic carboxylate-capped disulfide drug delivery system and its multifunctionality and multispatial targetability.
Authors: Choi, Yeon Su and Cho, Hana and Choi, Won-Gu and Lee, Sung Su and Huh, Kang Moo and Shim, Min Suk and Park, In Suh and Cho, Yong-Yeon and Lee, Joo Young and Lee, Hye Suk and Kang, Han Chang
Journal: Biomaterials (2022): 121307

A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes.
Authors: Talkington, Anne M and McSweeney, Morgan D and Wessler, Timothy and Rath, Marielle K and Li, Zibo and Zhang, Tao and Yuan, Hong and Frank, Jonathan E and Forest, M Gregory and Cao, Yanguang and Lai, Samuel K
Journal: Journal of controlled release : official journal of the Controlled Release Society (2022): 518-527

Subvisible Particles Derived by Dropping Stress Enhance Anti-PEG Antibody Production and Clearance of PEGylated Proteins in Mice.
Authors: Nakajima, Takaki and Nagano, Kazuya and Fukuda, Yuka and Ishima, Yu and Shibata, Hiroko and Isaka, Ryo and Zhang, Tian-Qi and Haga, Yuya and Higashisaka, Kazuma and Tsujino, Hirofumi and Ishida, Tatsuhiro and Ishii-Watabe, Akiko and Tsutsumi, Yasuo
Journal: Journal of pharmaceutical sciences (2022): 1363-1369

Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats.
Authors: Fang, Jia-Long and Vanlandingham, Michelle M and Beland, Frederick A and Felton, Robert P and Maisha, Mackean P and Olson, Greg R and Patton, Ralph E and Rosenberg, Amy S and Gamboa da Costa, Gonçalo
Journal: Toxicology letters (2022): 22-30

Using Bio-Layer Interferometry to Evaluate Anti-PEG Antibody-Mediated Complement Activation.
Authors: Mostafa, Mahmoud and Elsadek, Nehal E and Emam, Sherif E and Ando, Hidenori and Shimizu, Taro and Abdelkader, Hamdy and Ishima, Yu and Aly, Usama Farghaly and Sarhan, Hatem A and Ishida, Tatsuhiro
Journal: Biological & pharmaceutical bulletin (2022): 129-135

Impact of anti-PEG antibody affinity on accelerated blood clearance of pegylated epoetin beta in mice.
Authors: Chang, Tien-Ching and Chen, Bing-Mae and Wu, Jer-Yuan and Cheng, Tian-Lu and Roffler, Steve
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2022): 112502

Accelerated blood clearance and hypersensitivity by PEGylated liposomes containing TLR agonists.
Authors: Stavnsbjerg, Camilla and Christensen, Esben and Münter, Rasmus and Henriksen, Jonas R and Fach, Matthias and Parhamifar, Ladan and Christensen, Camilla and Kjaer, Andreas and Hansen, Anders E and Andresen, Thomas L
Journal: Journal of controlled release : official journal of the Controlled Release Society (2022): 337-344

Incorporating Gangliosides into PEGylated Cationic Liposomes that Complexed DNA Attenuates Anti-PEG Antibody Production but Not Anti-DNA Antibody Production in Mice.
Authors: Qelliny, Milad Reda and Shimizu, Taro and Elsadek, Nehal E and Emam, Sherif E and Takata, Haruka and Fathalla, Zeinab M A and Hussein, Amal K and Khaled, Khaled A and Ando, Hidenori and Ishima, Yu and Ishida, Tatsuhiro
Journal: Molecular pharmaceutics (2021): 2406-2415

Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies.
Authors: Chen, Bing-Mae and Cheng, Tian-Lu and Roffler, Steve R
Journal: ACS nano (2021): 14022-14048

Pre-treatment with high molecular weight free PEG effectively suppresses anti-PEG antibody induction by PEG-liposomes in mice.
Authors: McSweeney, Morgan D and Shen, Limei and DeWalle, Alexander C and Joiner, Jordan B and Ciociola, Elizabeth C and Raghuwanshi, Dharmendra and Macauley, Matthew S and Lai, Samuel K
Journal: Journal of controlled release : official journal of the Controlled Release Society (2021): 774-781