Name: NAADP-AM
Brand: AAT Bioquest
SKU: 20997
Availability: InStock

NAADP-AM

NAADP (nicotinic acid adenine dinucleotide phosphate) is a recently discovered second messenger. NAADP is negatively charged (to prevent it from leaking out of cells). The negative charge of NAADP makes it well retained in cells, but imposes difficulties in loading NAADP into live cells. NAADP must be injected, loaded via liposomes, or electroporated. These invasive techniques are highly technically demanding and are possible only in certain single cell preparations. NAADP-AM has been reported as a cell-permeant analog of NAADP. NAADP-AM can be taken into cells and induces NAADP-mediated calcium signaling. NAADP-AM can be used in a wide range of systems and will greatly facilitate research into the role of NAADP in biological research. The NAADP-AM consists of three NAADP AM esters with one major component and two minor AM esters.

Protocol

COA

Catalog	Size	Price
20997	2X50 ug	Price
20998	250 ug	Price
21000	1 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of NAADP-AM to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	96.839 µL	484.196 µL	968.392 µL	4.842 mL	9.684 mL
5 mM	19.368 µL	96.839 µL	193.678 µL	968.392 µL	1.937 mL
10 mM	9.684 µL	48.42 µL	96.839 µL	484.196 µL	968.392 µL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	1032.64 g/mol	=	mL	x	mM	=	mmol

Citations

View all 7 citations: Citation Explorer

Lysosomal TPC2 channel as a new target of chlorpromazine and Clomipramine to induce protective autophagy in L-BMAA-induced neurodegeneration

Authors:

Tedeschi, Valentina and Ciancio, Raffaella and Magliocca, Giorgia and Esposito, Emilia and Piccirillo, Silvia and Rubino, Valentina and Preziuso, Alessandra and Spadoni, Tatiana and Di Muraglia, Noemi and Ruggiero, Giuseppina and others,

Journal:

Biochemical Pharmacology (2025): 117219

MASTER-NAADP: a membrane permeable precursor of the Ca2+ mobilizing second messenger NAADP

Authors:

Krukenberg, Sarah and M{\"o}ckl, Franziska and Wei{\ss}, Mariella and Dekiert, Patrick and Hofmann, Melanie and Gerlach, Fynn and Winterberg, Kai J and Kovacevic, Dejan and Khansahib, Imrankhan and Troost, Berit and others,

Journal:

Nature Communications (2024): 8008

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Mediated Calcium Signaling Is Active in Memory CD4+ T Cells

Authors:

Chakraborty, Anish and Dissanayake, Ravindika and Wall, Katherine A

Journal:

Molecules (2024): 907

LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells

Authors:

Nabar, Neel R and Heijjer, Christopher N and Shi, Chong-Shan and Hwang, Il-Young and Ganesan, Sundar and Karlsson, Mikael CI and Kehrl, John H

Journal:

Autophagy (2021): 1--19

NAADP-induced intracellular calcium ion is mediated by the TPCs (two-pore channels) in hypoxia-induced pulmonary arterial hypertension

Authors:

Hu, Wen and Zhao, Fei and Chen, Ling and Ni, Jiamin and Jiang, Yongliang

Journal:

Journal of Cellular and Molecular Medicine (2021)

References

View all 149 references: Citation Explorer

Both RyRs and TPCs are required for NAADP-induced intracellular Ca release

Authors:

Gerasimenko JV, Charlesworth RM, Sherwood MW, Ferdek PE, Mikoshiba K, Parrington J, Petersen OH, Gerasimenko OV.

Journal:

Cell Calcium. (2015)

TPC: the NAADP discovery channel

Authors:

Morgan AJ, Davis LC, Ruas M, Galione A.

Journal:

Biochem Soc Trans (2015): 384

Role of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) in Keratinocyte Differentiation

Authors:

Park KH, Kim KN, Park DR, Jang KY, Kim UH.

Journal:

J Invest Dermatol (2015): 1692

A primer of NAADP-mediated Ca signalling: From sea urchin eggs to mammalian cells

Authors:

Galione A., undefined

Journal:

Cell Calcium (2015): 27

The role of calcium and nicotinic acid adenine dinucleotide phosphate (NAADP) in human osteoclast formation and resorption

Authors:

Cheng X, Hookway ES, Kashima T, Oppermann U, Galione A, Athanasou NA.

Journal:

Calcif Tissue Int (2015): 73

Physical properties

Molecular weight	1032.64
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -60 °C); Minimize light exposure
UNSPSC	12352200

Documents

Protocol
Safety Data Sheet (Catalog 20997)
Safety Data Sheet (Catalog 20998)
Safety Data Sheet (Catalog 21000)
Certificate of Analysis

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Page updated on October 27, 2025