Name: NAADP [Nicotinic acid adenine dinucleotide phosphate sodium salt] *CAS 5502-96-5*
Brand: AAT Bioquest
SKU: 20999
Price: 115 USD
Availability: InStock

NAADP

Nicotinic acid adenine dinucleotide phosphate sodium salt; CAS 5502-96-5

NAADP is a calcium mobilizing agent. NAADP initiates calcium release via type 1 ryanodine receptor (RyR1) activation. NAADP also regulates calcium release from intracellular stores distinct from the endoplasmic reticulum (ER), and displays affinity for two-pore channels (TPCs), which release calcium from acidic organelles.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
20999	1 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of Water needed to reconstitute specific mass of NAADP [Nicotinic acid adenine dinucleotide phosphate sodium salt] *CAS 5502-96-5* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	116.917 µL	584.583 µL	1.169 mL	5.846 mL	11.692 mL
5 mM	23.383 µL	116.917 µL	233.833 µL	1.169 mL	2.338 mL
10 mM	11.692 µL	58.458 µL	116.917 µL	584.583 µL	1.169 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	855.31 g/mol	=	mL	x	mM	=	mmol

References

View all 149 references: Citation Explorer

Both RyRs and TPCs are required for NAADP-induced intracellular Ca release

Authors:

Gerasimenko JV, Charlesworth RM, Sherwood MW, Ferdek PE, Mikoshiba K, Parrington J, Petersen OH, Gerasimenko OV.

Journal:

Cell Calcium. (2015)

A novel Ca(2)(+)-mediated cross-talk between endoplasmic reticulum and acidic organelles: implications for NAADP-dependent Ca(2)(+) signalling

Authors:

Ronco V, Potenza DM, Denti F, Vullo S, Gagliano G, Tognolina M, Guerra G, Pinton P, Genazzani AA, Mapelli L, Lim D, Moccia F.

Journal:

Cell Calcium (2015): 89

NAADP and endolysosomal two-pore channels modulate membrane excitability and stimulus-secretion coupling in mouse pancreatic beta cells

Authors:

Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Braun M, Zhang Q, Sones W, Shimomura K, Morgan AJ, Lewis AM, Chuang KT, Tunn R, Gadea J, Teboul L, Heister PM, Tynan PW, Bellomo EA, Rutter GA, Rorsman P, Churchill GC, Parrington J, Galione A.

Journal:

J Biol Chem. (2015)

The role of calcium and nicotinic acid adenine dinucleotide phosphate (NAADP) in human osteoclast formation and resorption

Authors:

Cheng X, Hookway ES, Kashima T, Oppermann U, Galione A, Athanasou NA.

Journal:

Calcif Tissue Int (2015): 73

A primer of NAADP-mediated Ca signalling: From sea urchin eggs to mammalian cells

Authors:

Galione A., undefined

Journal:

Cell Calcium (2015): 27

Physical properties

Molecular weight	855.31
Solvent	Water

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12352200
CAS	5502-96-5

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Page updated on October 6, 2025