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NAADP [Nicotinic acid adenine dinucleotide phosphate sodium salt] *CAS 5502-96-5*

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Physical properties
Molecular weight855.31
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure


Molecular weight
NAADP is a calcium mobilizing agent. NAADP initiates calcium release via type 1 ryanodine receptor (RyR1) activation. NAADP also regulates calcium release from intracellular stores distinct from the endoplasmic reticulum (ER), and displays affinity for two-pore channels (TPCs), which release calcium from acidic organelles.


Common stock solution preparation

Table 1. Volume of Water needed to reconstitute specific mass of NAADP [Nicotinic acid adenine dinucleotide phosphate sodium salt] *CAS 5502-96-5* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM116.917 µL584.583 µL1.169 mL5.846 mL11.692 mL
5 mM23.383 µL116.917 µL233.833 µL1.169 mL2.338 mL
10 mM11.692 µL58.458 µL116.917 µL584.583 µL1.169 mL

Molarity calculator

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View all 1 citations: Citation Explorer
NAADP-mediated Ca2+ signaling promotes autophagy and protects against LPS-induced liver injury
Authors: Rah, So-Young and Lee, Young-Hoon and Kim, Uh-Hyun
Journal: The FASEB Journal (2017): fj--201601290R


View all 149 references: Citation Explorer
Both RyRs and TPCs are required for NAADP-induced intracellular Ca release
Authors: Gerasimenko JV, Charlesworth RM, Sherwood MW, Ferdek PE, Mikoshiba K, Parrington J, Petersen OH, Gerasimenko OV.
Journal: Cell Calcium. (2015)
A novel Ca(2)(+)-mediated cross-talk between endoplasmic reticulum and acidic organelles: implications for NAADP-dependent Ca(2)(+) signalling
Authors: Ronco V, Potenza DM, Denti F, Vullo S, Gagliano G, Tognolina M, Guerra G, Pinton P, Genazzani AA, Mapelli L, Lim D, Moccia F.
Journal: Cell Calcium (2015): 89
NAADP and endolysosomal two-pore channels modulate membrane excitability and stimulus-secretion coupling in mouse pancreatic beta cells
Authors: Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Braun M, Zhang Q, Sones W, Shimomura K, Morgan AJ, Lewis AM, Chuang KT, Tunn R, Gadea J, Teboul L, Heister PM, Tynan PW, Bellomo EA, Rutter GA, Rorsman P, Churchill GC, Parrington J, Galione A.
Journal: J Biol Chem. (2015)
The role of calcium and nicotinic acid adenine dinucleotide phosphate (NAADP) in human osteoclast formation and resorption
Authors: Cheng X, Hookway ES, Kashima T, Oppermann U, Galione A, Athanasou NA.
Journal: Calcif Tissue Int (2015): 73
A primer of NAADP-mediated Ca signalling: From sea urchin eggs to mammalian cells
Authors: Galione A., undefined
Journal: Cell Calcium (2015): 27
Role of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) in Keratinocyte Differentiation
Authors: Park KH, Kim KN, Park DR, Jang KY, Kim UH.
Journal: J Invest Dermatol (2015): 1692
TPC: the NAADP discovery channel
Authors: Morgan AJ, Davis LC, Ruas M, Galione A.
Journal: Biochem Soc Trans (2015): 384
Characterization of NAADP-mediated calcium signaling in human spermatozoa
Authors: Sanchez-Tusie AA, Vasudevan SR, Churchill GC, Nishigaki T, Trevino CL.
Journal: Biochem Biophys Res Commun (2014): 531
Synthesis of caged NAADP
Authors: Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC.
Journal: Cold Spring Harb Protoc (2014): pdb prot076943
Activity of nicotinic acid substituted nicotinic acid adenine dinucleotide phosphate (NAADP) analogs in a human cell line: difference in specificity between human and sea urchin NAADP receptors
Authors: Ali RA, Zhelay T, Trabbic CJ, Walseth TF, Slama JT, Giovannucci DR, Wall KA.
Journal: Cell Calcium (2014): 93