Name: OG488 maleimide [equivalent to Oregon Green® 488 maleimide]
Brand: AAT Bioquest
SKU: 715
Price: 232 USD
Availability: InStock

OG488 maleimide

equivalent to Oregon Green® 488 maleimide

OG488 maleimide is the same molecule to Oregon Green® 488 maleimide (Invitrogen #O6034, Oregon Green® is the Trademark of Invitrogen). This fluorinated analog of fluorescein has higher photostability and a lower pKa ~ 4.7 while fluorescein maleimide has pKa ~6.4. The decreased pKa of OG488 maleimide makes its fluorescence essentially pH insensitive in the physiological pH range. This thiol-reactive OG488 maleimide can be used to make bright green fluorescent bioconjugates with excitation/emission maxima ~496/524 nm. It is an excellent replacement to fluorescein maleimide that has severe pH dependence and low photostability.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
715	5 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of OG488 maleimide [equivalent to Oregon Green® 488 maleimide] to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	215.82 µL	1.079 mL	2.158 mL	10.791 mL	21.582 mL
5 mM	43.164 µL	215.82 µL	431.639 µL	2.158 mL	4.316 mL
10 mM	21.582 µL	107.91 µL	215.82 µL	1.079 mL	2.158 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	463.35 g/mol	=	mL	x	mM	=	mmol

References

View all 14 references: Citation Explorer

Biodegradable polymersomes as carriers and release systems for paclitaxel using Oregon Green(R) 488 labeled paclitaxel as a model compound

Authors:

Lee JS, Feijen J.

Journal:

J Control Release (2012): 312

Microscopic imaging of intracellular calcium in live cells using lifetime-based ratiometric measurements of Oregon Green BAPTA-1

Authors:

Lattarulo C, Thyssen D, Kuchibholta KV, Hyman BT, Bacskaiq BJ.

Journal:

Methods Mol Biol (2011): 377

Pharmacokinetics of intraocular drug delivery of Oregon green 488-labeled triamcinolone by subtenon injection using ocular fluorophotometry in rabbit eyes

Authors:

Lee SJ, Kim ES, Geroski DH, McCarey BE, Edelhauser HF.

Journal:

Invest Ophthalmol Vis Sci (2008): 4506

Trans-scleral permeability of Oregon green 488

Authors:

Lee SJ, Kim SJ, Kim ES, Geroski DH, McCarey BE, Edelhauser HF.

Journal:

J Ocul Pharmacol Ther (2008): 579

The Pennsylvania Green Fluorophore: a hybrid of Oregon Green and Tokyo Green for the construction of hydrophobic and pH-insensitive molecular probes

Authors:

Mottram LF, Boonyarattanakalin S, Kovel RE, Peterson BR.

Journal:

Org Lett (2006): 581

Physical properties

Molecular weight	463.35
Solvent	DMSO

Spectral properties

Correction factor (260 nm)	0.31
Correction factor (280 nm)	0.12
Extinction coefficient (cm ^-1 M ^-1)	76000
Excitation (nm)	498
Emission (nm)	526

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

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Page updated on October 13, 2025