OG488 Taxol Conjugate

OG488 Taxol Conjugate is the same compound as Oregon Green® 488 paclitaxel (also known as Flutax-2). Taxol, also known as Paclitaxel, is an anticancer agent. Taxol is known to promote tubulin assembly into stable aggregated structures. The green fluorescent OG488 Taxol Conjugate is an effective fluorescent probe for studying microtubules in cells and in solutions. The fluorescent label OG488 is attached to paclitaxel by derivatization of the 7-β-hydroxy group of native paclitaxel, minimizing the interference of OG488 fluorophore on the binding of the probe to microtubules. OG488 Taxol Conjugate has been successfully used for live-cell tubulin labeling. The binding of OG488 Taxol Conjugate to microtubules can be conveniently analyzed either by FACS or fluorescence imaging.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
23175	5x50 ug	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of OG488 Taxol Conjugate to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	75.799 µL	378.995 µL	757.989 µL	3.79 mL	7.58 mL
5 mM	15.16 µL	75.799 µL	151.598 µL	757.989 µL	1.516 mL
10 mM	7.58 µL	37.899 µL	75.799 µL	378.995 µL	757.989 µL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	1319.28 g/mol	=	mL	x	mM	=	mmol

References

View all 5 references: Citation Explorer

Paclitaxel-loaded expansile nanoparticles enhance chemotherapeutic drug delivery in mesothelioma 3-dimensional multicellular spheroids.

Authors:

Lei, Hongyi and Hofferberth, Sophie C and Liu, Rong and Colby, Aaron and Tevis, Kristie M and Catalano, Paul and Grinstaff, Mark W and Colson, Yolonda L

Journal:

The Journal of thoracic and cardiovascular surgery (2015): 1417-24; discussion 1424-25.e1

Killed Bacillus subtilis spores expressing streptavidin: a novel carrier of drugs to target cancer cells.

Authors:

Nguyen, Van Anh Thi and Huynh, Hong Anh and Hoang, Tong Van and Ninh, Ngoc Thi and Pham, An Thi Hong and Nguyen, Hoa Anh and Phan, Tuan-Nghia and Cutting, Simon M

Journal:

Journal of drug targeting (2013): 528-41

Biodegradable polymersomes as carriers and release systems for paclitaxel using Oregon Green® 488 labeled paclitaxel as a model compound.

Authors:

Lee, Jung Seok and Feijen, Jan

Journal:

Journal of controlled release : official journal of the Controlled Release Society (2012): 312-8

Drug resistance to paclitaxel is not only associated with ABCB1 mRNA expression but also with drug accumulation in intracellular compartments in human lung cancer cell lines.

Authors:

Shimomura, Masanori and Yaoi, Takeshi and Itoh, Kyoko and Kato, Daishiro and Terauchi, Kunihiko and Shimada, Junichi and Fushiki, Shinji

Journal:

International journal of oncology (2012): 995-1004

Direct assessment of P-glycoprotein efflux to determine tumor response to chemotherapy.

Authors:

Patwardhan, Gauri and Gupta, Vineet and Huang, Juowen and Gu, Xin and Liu, Yong-Yu

Journal:

Biochemical pharmacology (2010): 72-9

Physical properties

Molecular weight	1319.28
Solvent	DMSO

Spectral properties

Correction factor (260 nm)	0.31
Correction factor (280 nm)	0.12
Extinction coefficient (cm ^-1 M ^-1)	76000
Excitation (nm)	498
Emission (nm)	526

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure

Documents

Protocol
Safety Data Sheet
Certificate of Analysis

Telephone
Fax
Email	sales@aatbio.com
International	See distributors
Bulk request	Inquire
Custom size	Inquire
Technical Support	Contact us
Request quotation	Request
Purchase order	Send to sales@aatbio.com
Shipping	Standard overnight for United States, inquire for international

Page updated on December 6, 2025