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Oxazine 1 *CAS 24796-94-9*

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Physical properties
Molecular weight423.89
Spectral properties
Extinction coefficient (cm -1 M -1)123000
Excitation (nm)648
Emission (nm)668
Quantum yield0.11001
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure


Molecular weight
Extinction coefficient (cm -1 M -1)
Excitation (nm)
Emission (nm)
Quantum yield
Oxazine 1 is one of the most fluorescent NIR dyes. It has maximum absorption around ~650 nm with extinction coefficient larger than 100,000 M-1 cm-1. It has fluorescence emission around 670 nm, which is pH-independent. Although Oxazine 1 is quite stable from pH 4 to pH 10, it might be reduced by some biological molecules (such as DTT, GSH etc) at high concentration. Oxazine 1 is also an efficient laser dye tunable around 670 nm.


Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Oxazine 1 *CAS 24796-94-9* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM235.91 µL1.18 mL2.359 mL11.796 mL23.591 mL
5 mM47.182 µL235.91 µL471.821 µL2.359 mL4.718 mL
10 mM23.591 µL117.955 µL235.91 µL1.18 mL2.359 mL

Molarity calculator

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Spectral properties

Extinction coefficient (cm -1 M -1)123000
Excitation (nm)648
Emission (nm)668
Quantum yield0.11001



View all 3 citations: Citation Explorer
Monitoring Methionine Decarboxylase by a Supramolecular Tandem Assay
Authors: Zheng, Zhe and Ren, Siying and Geng, Wen-Chao and Cui, Xuexian and Wu, Bian and Wang, Hong
Journal: Chemistry--An Asian Journal (2022): e202200106
A general method to improve fluorophores for live-cell and single-molecule microscopy
Authors: Grimm, Jonathan B and English, Brian P and Chen, Jiji and Slaughter, Joel P and Zhang, Zhengjian and Revyakin, Andrey and Patel, Ronak and Macklin, John J and Normanno, Davide and Singer, Robert H and others, undefined
Journal: Nature methods (2015): 244--250


View all 11 references: Citation Explorer
Controlling the fluorescence of ordinary oxazine dyes for single-molecule switching and superresolution microscopy
Authors: Vogelsang J, Cordes T, Forthmann C, Steinhauer C, Tinnefeld P.
Journal: Proc Natl Acad Sci U S A (2009): 8107
Analysis of wave packet motion in frequency and time domain: oxazine 1
Authors: Braun M, Sobotta C, Durr R, Pulvermacher H, Malkmus S.
Journal: J Phys Chem A (2006): 9793
Effects of pH and electrolyte concentration on the binding between a humic acid and an oxazine dye
Authors: Zanini GP, Avena MJ, Fiol S, Arce F.
Journal: Chemosphere (2006): 430
Chirp dependence of wave packet motion in oxazine 1
Authors: Malkmus S, Durr R, Sobotta C, Pulvermacher H, Zinth W, Braun M.
Journal: J Phys Chem A (2005): 10488
Oxazine 170 induces DNA:RNA:DNA triplex formation
Authors: Song G, Xing F, Qu X, Chaires JB, Ren J.
Journal: J Med Chem (2005): 3471
In vivo detection of amyloid-beta deposits by near-infrared imaging using an oxazine-derivative probe
Authors: Hintersteiner M, Enz A, Frey P, Jaton AL, Kinzy W, Kneuer R, Neumann U, Rudin M, Staufenbiel M, Stoeckli M, Wiederhold KH, Gremlich HU.
Journal: Nat Biotechnol (2005): 577
Cytochrome P450 modification by a new oxazine derivative with hypolipidemic activity
Authors: Chrysselis MC, Rekka EA, Kourounakis PN.
Journal: Res Commun Mol Pathol Pharmacol (2000): 325
Identification of neutrophils with an oxazine dye
Authors: Kass L., undefined
Journal: Am J Clin Pathol (1987): 436
Flow cytometry of DNA content using oxazine 750 or related laser dyes with 633 nm excitation
Authors: Shapiro HM, Stephens S.
Journal: Cytometry (1986): 107
Oxazine dyes. IV. Simultaneous nuclear and double-contrast cytoplasmic staining from a single solution
Authors: Nathan MJ, Gray P.
Journal: Stain Technol (1961): 237