Phalloidin lysine

Phalloidin lysine is a convenient building block that can be used for developing a variety of phalloidin derivatives that may be for studying cellular structures and other biological applications. It readily reacts with amine-reactive dyes, biotins and other tag molecules (such as NHS esters, isothiocyanates and sulfonyl chlorides etc). Phalloidin, a bicyclic heptapeptide toxin, binds specifically at the interface between F-actin subunits, locking adjacent subunits together. Phalloidin binds to actin filaments much more tightly than to actin monomers, leading to a decrease in the rate constant for the dissociation of actin subunits from filament ends, essentially stabilizing actin filaments through the prevention of filament depolymerization. The property of phalloidin is a useful tool for investigating the distribution of F-actin in cells by labeling phalloidin with fluorescent analogs and using them to stain actin filaments for light microscopy. Fluorescent derivatives of phalloidin have turned out to be enormously useful in localizing actin filaments in living or fixed cells as well as for visualizing individual actin filaments in vitro. Fluorescent phalloidin derivatives have been used as an important tool in the study of actin networks at high resolution. AAT Bioquest offers a variety of fluorescent phalloidin derivatives with different colors for multicolor imaging applications.

Protocol

COA

Catalog	Size	Price	Quantity
5304	100 ug	Price
5305	1 mg	Price

References

View all 7 references: Citation Explorer

Hybrid elastomer-plastic microfluidic device as a convenient model for mimicking the blood-brain barrier in vitro.

Authors:

Nguyen, Phuoc Quang Huy and Duong, Duong Duy and Kwun, Jun Dae and Lee, Nae Yoon

Journal:

Biomedical microdevices (2019): 90

Purinergic Signaling and Aminoglycoside Ototoxicity: The Opposing Roles of P1 (Adenosine) and P2 (ATP) Receptors on Cochlear Hair Cell Survival.

Authors:

Lin, Shelly C Y and Thorne, Peter R and Housley, Gary D and Vlajkovic, Srdjan M

Journal:

Frontiers in cellular neuroscience (2019): 207

Gross anatomy of the muscle systems and associated innervation of Apatemon cobitidis proterorhini metacercaria (Trematoda: Strigeidea), as visualized by confocal microscopy.

Authors:

Stewart, M T and Mousley, A and Koubková, B and Sebelová, S and Marks, N J and Halton, D W

Journal:

Parasitology (2003): 273-82

Light and electron microscopic study of changes in the organization of the cortical actin cytoskeleton during chromaffin cell secretion.

Authors:

Tchakarov, L E and Zhang, L and Rosé, S D and Tang, R and Trifaró, J M

Journal:

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society (1998): 193-203

Responses induced by tacrine in neuronal and non-neuronal cell lines.

Authors:

De Ferrari, G V and von Bernhardi, R and Calderón, F H and Luza, S C and Inestrosa, N C

Journal:

Journal of neuroscience research (1998): 435-44

Physical properties

Molecular weight	885.91
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

Documents

Protocol
Safety Data Sheet (Catalog 5304)
Safety Data Sheet (Catalog 5305)
Certificate of Analysis

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Page updated on October 19, 2025