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Rapamycin-LC-Fluorescein
Rapamycin-LC-Fluorescein is an excellent fluorescent probe to characterize FK506-binding proteins by fluorescence polarization. It has moderate affinity for the FK1 domains of FKBPS1 (177 nM) and FKBP2 (469 nM). It can be used for active-site titrations, competition assays with unlabeled ligands and enable a robust, miniaturized assay adequate for high-throughput screening. FK506-binding proteins (FKBPs) convey the immunosuppressive action of FK506 and rapamycin and mediate the neuroprotective properties of these compounds and participate in the regulation of calcium channels. In addition, the larger homologues FKBP51 and FKBP52 act as cochaperones for Hsp90 and regulate the transactivation activity of steroid hormone receptors.
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References
View all 50 references: Citation Explorer
A pH-response-based fluorescent probe for detecting the mitophagy process by tracing changes in colocalization coefficients.
Authors: Hao, Nongyi and Jiang, Zekun and Zhou, Lina and Dai, Xiaoyu and Kong, Xiuqi
Journal: Analytical methods : advancing methods and applications (2024): 2241-2247
Authors: Hao, Nongyi and Jiang, Zekun and Zhou, Lina and Dai, Xiaoyu and Kong, Xiuqi
Journal: Analytical methods : advancing methods and applications (2024): 2241-2247
Verteporfin fluorescence in antineoplastic-treated pancreatic cancer cells found concentrated in mitochondria.
Authors: Zhang, Ying-Qiao and Liu, Qing-Hao and Liu, Lu and Guo, Peng-Yu and Wang, Run-Ze and Ba, Zhi-Chang
Journal: World journal of gastrointestinal oncology (2024): 968-978
Authors: Zhang, Ying-Qiao and Liu, Qing-Hao and Liu, Lu and Guo, Peng-Yu and Wang, Run-Ze and Ba, Zhi-Chang
Journal: World journal of gastrointestinal oncology (2024): 968-978
A Systematic Design and Synthesis of PET-based Fluorescent Probes for Monitoring pH During Mitophagy.
Authors: Yadav, Rashmi and Munan, Subrata and Ali, Mudassar and Mapa, Koyeli and Samanta, Animesh
Journal: Chemistry, an Asian journal (2023): e202300308
Authors: Yadav, Rashmi and Munan, Subrata and Ali, Mudassar and Mapa, Koyeli and Samanta, Animesh
Journal: Chemistry, an Asian journal (2023): e202300308
Fluorescent probe for the identification of potent inhibitors of the macrophage infectivity potentiator (Mip) protein of Burkholderia pseudomallei.
Authors: Scheuplein, Nicolas Julian and Lohr, Theresa and Vivoli Vega, Mirella and Ankrett, Dyan and Seufert, Florian and Kirchner, Lukas and Harmer, Nicholas J and Holzgrabe, Ulrike
Journal: SLAS discovery : advancing life sciences R & D (2023): 211-222
Authors: Scheuplein, Nicolas Julian and Lohr, Theresa and Vivoli Vega, Mirella and Ankrett, Dyan and Seufert, Florian and Kirchner, Lukas and Harmer, Nicholas J and Holzgrabe, Ulrike
Journal: SLAS discovery : advancing life sciences R & D (2023): 211-222
A Reversible Fluorescent Probe for In Situ Monitoring Redox Imbalance during Mitophagy.
Authors: Li, Junbin and Song, Lifei and Hu, Weiguo and Zuo, Qin and Li, Roumei and Dai, Min and Zhou, Yibo and Qing, Zhihe
Journal: Analytical chemistry (2023): 13668-13673
Authors: Li, Junbin and Song, Lifei and Hu, Weiguo and Zuo, Qin and Li, Roumei and Dai, Min and Zhou, Yibo and Qing, Zhihe
Journal: Analytical chemistry (2023): 13668-13673
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