RH 237 [N-(4-Sulfobutyl)-4-(6-(4-(dibutylamino)phenyl)hexatrienyl)pyridinium, inner salt]

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Physical properties

Molecular weight	496.7
Solvent	DMSO

Spectral properties

Excitation (nm)	550
Emission (nm)	786

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12352200

Overview SDS Protocol

Molecular weight

496.7

Excitation (nm)

550

Emission (nm)

786

RH 237, also called N-(4-sulfobutyl)-4-(6-(4-(dibutylamino)phenyl)hexatrienyl)pyridinium, is a neuron-tracing dye. It is used for monitoring membrane potential, synaptic activity and ion channel activity of neurons.

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of RH 237 [N-(4-Sulfobutyl)-4-(6-(4-(dibutylamino)phenyl)hexatrienyl)pyridinium, inner salt] to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	201.329 µL	1.007 mL	2.013 mL	10.066 mL	20.133 mL
5 mM	40.266 µL	201.329 µL	402.658 µL	2.013 mL	4.027 mL
10 mM	20.133 µL	100.664 µL	201.329 µL	1.007 mL	2.013 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
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Spectrum

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Spectral properties

Excitation (nm)	550
Emission (nm)	786

Images

Figure 1. Chemical structure for RH 237 [N-(4-Sulfobutyl)-4-(6-(4-(dibutylamino)phenyl)hexatrienyl)pyridinium, inner salt]

Citations

View all 6 citations: Citation Explorer

The effect of sex and age on ex vivo cardiac electrophysiology: insight from a guinea pig model
Authors: Haq, Kazi T and Cooper, Blake L and Berk, Fiona and Posnack, Nikki G
Journal: American Journal of Physiology-Heart and Circulatory Physiology (2022)

Optocardiography and electrophysiology studies of ex vivo langendorff-perfused hearts
Authors: Swift, Luther M and Jaimes III, Rafael and McCullough, Damon and Burke, Morgan and Reilly, Marissa and Maeda, Takuya and Zhang, Hanyu and Ishibashi, Nobuyuki and Rogers, Jack M and Posnack, Nikki Gillum
Journal: Journal of visualized experiments: JoVE (2019)

Translational Physiology: Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds
Authors: Hull, Christina M and Genge, Christine E and Hobbs, Yuki and Rayani, Kaveh and Lin, Eric and Gunawan, Marvin and Shafaattalab, Sanam and Tibbits, Glen F and Claydon, Tom W
Journal: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (2019): R921

Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds
Authors: Hull, Christina M and Genge, Christine E and Hobbs, Yuki and Rayani, Kaveh and Lin, Eric and Gunawan, Marvin and Shafaattalab, Sanam and Tibbits, Glen F and Claydon, Tom W
Journal: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (2019): R921--R931

Age-associated changes in electrical function of the zebrafish heart
Authors: Stoyek, Matthew R and Rog-Zielinska, Eva A and Quinn, T Alex and er, undefined
Journal: Progress in biophysics and molecular biology (2018)

Long non-coding RNA CCRR controls cardiac conduction via regulating intercellular coupling
Authors: Zhang, Yong and Sun, Lihua and Xuan, Lina and Pan, Zhenwei and Hu, Xueling and Liu, Hongyu and Bai, Yunlong and Jiao, Lei and Li, Zhange and Cui, Lina and others, undefined
Journal: Nature communications (2018): 4176

References

View all 11 references: Citation Explorer

Contrasting effects of ischemia on the kinetics of membrane voltage and intracellular calcium transient underlie electrical alternans
Authors: Lakireddy V, Baweja P, Syed A, Bub G, Boutjdir M, El-Sherif N.
Journal: Am J Physiol Heart Circ Physiol (2005): H400

Second-harmonic generation sensitivity to transmembrane potential in normal and tumor cells
Authors: Sacconi L, D'Amico M, Vanzi F, Biagiotti T, Antolini R, Olivotto M, Pavone FS.
Journal: J Biomed Opt (2005): 24014

Simultaneous optical imaging of membrane potential and intracellular calcium
Authors: Fast VG., undefined
Journal: J Electrocardiol (2005): 107

Intracellular Ca dynamics in ventricular fibrillation
Authors: Omichi C, Lamp ST, Lin SF, Yang J, Baher A, Zhou S, Attin M, Lee MH, Karagueuzian HS, Kogan B, Qu Z, Garfinkel A, Chen PS, Weiss JN.
Journal: Am J Physiol Heart Circ Physiol (2004): H1836

Effects of electrical shocks on Cai2+ and Vm in myocyte cultures
Authors: Fast VG, Cheek ER, Pollard AE, Ideker RE.
Journal: Circ Res (2004): 1589

Development of an optrode for intramural multisite optical recordings of Vm in the heart
Authors: Byars JL, Smith WM, Ideker RE, Fast VG.
Journal: J Cardiovasc Electrophysiol (2003): 1196

Simultaneous optical mapping of transmembrane potential and intracellular calcium in myocyte cultures
Authors: Fast VG, Ideker RE.
Journal: J Cardiovasc Electrophysiol (2000): 547

Spatial changes in transmembrane potential during extracellular electrical shocks in cultured monolayers of neonatal rat ventricular myocytes
Authors: Gillis AM, Fast VG, Rohr S, Kleber AG.
Journal: Circ Res (1996): 676

Fluorescent styryl dyes of the RH series affect a potential drop on the membrane/solution boundary
Authors: Malkov DY, Sokolov VS.
Journal: Biochim Biophys Acta (1996): 197

Microscopic conduction in cultured strands of neonatal rat heart cells measured with voltage-sensitive dyes
Authors: Fast VG, Kleber AG.
Journal: Circ Res (1993): 914