Salinomycin-BSA conjugate

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Physical properties

Molecular weight	N/A
Solvent	Water

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

Overview SDS Protocol

Molecular weight

N/A

Salinomycin is a polyether monocarboxylic acid produced by Streptomyces albus. It is used in the prevention of coccidiosis in poultry caused by E. necatrix, E. tenella, E. acervulina, E. brunette, E. maxima, and E. mivati. Salinomycin is active against certain Gram-positive bacteria, whereas Enterobacteriaceae are resistant. Salinomycin also has an inhibitory effect on Clostridium perfringens, thus the use of salinomycin leads to a decrease in the incidence of necrotic enteritis in broiler chickens. Salinomycin is considered as the marker residue and skin/fat as the target tissue. Salinomycin produces relatively low residue levels in the eggs compared with other polyether ionophores. Salinomycin-BSA conjugate is used for developing and screening Salinomycin antibodies. It is also an excellent reagent for quantifying Salinomycin by ELISA.

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Figure 1. Chemical structure for Salinomycin-BSA conjugate.

References

View all 15 references: Citation Explorer

Simultaneous immunodetection of ionophore antibiotics, salinomycin and narasin, in poultry products and milk.
Authors: Burkin, Maksim A and Galvidis, Inna A
Journal: Analytical methods : advancing methods and applications (2021): 1550-1558

Salinomycin Modulates the Expression of mRNAs and miRNAs Related to Stemness in Endometrial Cancer.
Authors: Talkowski, Karol and Kiełbasiński, Kamil and Peszek, Wojciech and Grabarek, Beniamin O and Boroń, Dariusz and Oplawski, Marcin
Journal: Current pharmaceutical biotechnology (2021): 317-326

Evaluation of Variances in VEGF-A-D and VEGFR-1-3 Expression in the Ishikawa Endometrial Cancer Cell Line Treated with Salinomycin and An-ti-Angiogenic/Lymphangiogenic Effect.
Authors: Kras, Piotr and Talkowski, Karol and Grabarek, Beniamin Oskar and Dziobek, Nina and Boroń, Dariusz and Oplawski, Marcin
Journal: Current pharmaceutical biotechnology (2020)

Effect of Salinomycin on Expression Pattern of Genes Associated with Apoptosis in Endometrial Cancer Cell Line.
Authors: Kiełbasiński, Kamil and Peszek, Wojciech and Grabarek, Beniamin O and Boroń, Dariusz and Wierzbik-Strońska, Magdalena and Oplawski, Marcin
Journal: Current pharmaceutical biotechnology (2020): 1269-1277

Combination of salinomycin and radiation effectively eliminates head and neck squamous cell carcinoma cells in vitro.
Authors: Gehrke, Thomas and Hackenberg, Stephan and Polat, Bülent and Wohlleben, Gisela and Hagen, Rudolf and Kleinsasser, Norbert and Scherzad, Agmal
Journal: Oncology reports (2018): 1991-1998

Salinomycin Abolished STAT3 and STAT1 Interactions and Reduced Telomerase Activity in Colorectal Cancer Cells.
Authors: Chung, Seyung S and Adekoya, Debbie and Enenmoh, Ikechukwu and Clarke, Orette and Wang, Piwen and Sarkyssian, Marianna and Wu, Yong and Vadgama, Jaydutt V
Journal: Anticancer research (2017): 445-453

Geno- and cytotoxicity of salinomycin in human nasal mucosa and peripheral blood lymphocytes.
Authors: Scherzad, Agmal and Hackenberg, Stephan and Schramm, Carolin and Froelich, Katrin and Ginzkey, Christian and Hagen, Rudolf and Kleinsasser, Norbert
Journal: Toxicology in vitro : an international journal published in association with BIBRA (2015): 813-8

Phenethyl isothiocyanate upregulates death receptors 4 and 5 and inhibits proliferation in human cancer stem-like cells.
Authors: Wang, Dan and Upadhyaya, Bijaya and Liu, Yi and Knudsen, David and Dey, Moul
Journal: BMC cancer (2014): 591

Sample treatment platform using nanoparticles to determine salinomycin in flesh and meat.
Authors: Park, Jihyun and Lim, H B
Journal: Food chemistry (2014): 112-7

Biodegradation of polyether algal toxins--isolation of potential marine bacteria.
Authors: Shetty, Kateel G and Huntzicker, Jacqueline V and Rein, Kathleen S and Jayachandran, Krish
Journal: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering (2010): 1850-7