Name: SMPEG2
Brand: AAT Bioquest
SKU: 4510
Price: 108 USD
Availability: InStock

SMPEG2

SM(PEG)2 is an amine-to-sulfhydryl crosslinkers with 17.6 angstroms length. It has an amino group-reactive NHS ester and sulfhydryl group-reactive maleimide. The N-hydroxysuccinimide ester (NHS) group reacts specifically and efficiently with lysine and N-terminal amino groups at pH 7-9 to form stable amide bonds. The maleimide group reacts with reduced sulfhydryls at pH 6.5-7.5 to form stable thioether bonds. SM(PEG)2 is used for irreversibly crosslinking proteins or peptides by flexible PEG spacer arms. The PEG arms help maintain conjugate solubility, reducing tendency toward aggregation and immunogenicity. It is ideal for performing controlled, two-step protein conjugations as SMCC.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
4510	25 mg	Price

References

View all 49 references: Citation Explorer

Cross-linking of bovine rhodopsin with sulfosuccinimidyl 4-(N maleimidomethyl)cyclohexane-1-carboxylate affects its functionality.

Authors:

Medina, Rafael and Perdomo, Deisy and Möller, Carolina and Bubis, José

Journal:

The Biochemical journal (2020)

Biocompatible Organic Coatings Based on Bisphosphonic Acid RGD-Derivatives for PEO-Modified Titanium Implants.

Authors:

Parfenova, Lyudmila V and Lukina, Elena S and Galimshina, Zulfia R and Gil'fanova, Guzel U and Mukaeva, Veta R and Farrakhov, Ruzil G and Danilko, Ksenia V and Dyakonov, Grigory S and Parfenov, Evgeny V

Journal:

Molecules (Basel, Switzerland) (2020)

Dietary Pattern Specific Protein Biomarkers for Cardiovascular Disease: A Cross-Sectional Study in 2 Independent Cohorts.

Authors:

Warensjö Lemming, Eva and Byberg, Liisa and Stattin, Karl and Ahmad, Shafqat and Lind, Lars and Elmståhl, Sölve and Larsson, Susanna C and Wolk, Alicja and Michaëlsson, Karl

Journal:

Journal of the American Heart Association (2019): e011860

Evaluation of the bioactivity about anti-sca-1/basic fibroblast growth factor-urinary bladder matrix scaffold for pelvic reconstruction.

Authors:

Li, Jiankui and Chen, Xi and Ling, Kaijian and Liang, Zhiqing and Xu, Huicheng

Journal:

Journal of biomaterials applications (2019): 808-818

Physical activity is associated with a large number of cardiovascular-specific proteins: Cross-sectional analyses in two independent cohorts.

Authors:

Stattin, Karl and Lind, Lars and Elmståhl, Sölve and Wolk, Alicja and Lemming, Eva Warensjö and Melhus, Håkan and Michaëlsson, Karl and Byberg, Liisa

Journal:

European journal of preventive cardiology (2019): 1865-1873

Physical properties

Molecular weight	425.39
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

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Page updated on October 14, 2025