TF2-HQKLVFFAK-TQ2 [TF2-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Lys-TQ2]

TF2-HQKLVFFAK-TQ2

TF2-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Lys-TQ2

TF2-HQKLVFFAK-TQ2 [TF2-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Lys-TQ2] has much stronger fluoresce upon protease cleavage than the commonly used FRET peptide MCA-HQKLVFFA (K-DNP), a secretase FRET peptide substrate. In addition, the fluorescence of TF2 has much longer wavelength fluorescence than MCA, minimalizing the interference caused by the sample autofluorescence.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
13206	1 mg	Price

References

View all 50 references: Citation Explorer

Endosome and Lysosome Membrane Properties Functionally Link to γ-Secretase in Live/Intact Cells.

Authors:

Houser, Mei C Q and Mitchell, Shane P C and Sinha, Priyanka and Lundin, Brianna and Berezovska, Oksana and Maesako, Masato

Journal:

Sensors (Basel, Switzerland) (2023)

In-Depth Characterization of Endo-Lysosomal Aβ in Intact Neurons.

Authors:

McKendell, Alec K and Houser, Mei C Q and Mitchell, Shane P C and Wolfe, Michael S and Berezovska, Oksana and Maesako, Masato

Journal:

Biosensors (2022)

A novel synthetic derivative of biaryl guanidine as a potential BACE1 inhibitor, to treat Alzheimer's disease: In-silico, in-vitro and in-vivo evaluation.

Authors:

Ali, Sayyad and Hassan Bin Asad, Muhammad Hassham and Javed, Muhammad Arslan and Javed, Tariq and Al-Kharaman, Yasser Msa and Latif, Muhammad and Mohsin, Sabeeh and Nawaz, Taufiq and Farid Hasan, Syed Muhammad and Iqbal, Jamshed and Babak, Borhan and Hussain, Izhar

Journal:

Pakistan journal of pharmaceutical sciences (2022): 1339-1345

Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1.

Authors:

Dai, Gucan

Journal:

The Journal of general physiology (2022)

Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons.

Authors:

Maesako, Masato and Houser, Mei C Q and Turchyna, Yuliia and Wolfe, Michael S and Berezovska, Oksana

Journal:

The Journal of neuroscience : the official journal of the Society for Neuroscience (2022): 145-154

Physical properties

Solvent

DMSO

Spectral properties

Extinction coefficient (cm ^-1 M ^-1)	80000
Excitation (nm)	500
Emission (nm)	522

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure

Documents

Protocol
Safety Data Sheet
Certificate of Analysis

Telephone
Fax
Email	sales@aatbio.com
International	See distributors
Bulk request	Inquire
Custom size	Inquire
Technical Support	Contact us
Request quotation	Request
Purchase order	Send to sales@aatbio.com
Shipping	Standard overnight for United States, inquire for international

Page updated on November 21, 2025