Thioflavin S *CAS 1326-12-1*

Thioflavin S

CAS 1326-12-1

Thioflavin S is a mixture of compounds that results from the methylation of dehydrothiotoluidine with sulphonic acid. It is also used to stain Alzheimer's plaques as ThT.

<p>The staining of Thioflavin S (in green) on adjacent sections of the hippocampus of a patient suffering from Alzheimer's disease. Thioflavin S binds both senile plaques (SP) and neurofibrillary tangles (NFT), the two characteristic cortical lesions of Alzheimer's. Amyloid beta is a peptide derived from the amyloid precursor protein which is only found in senile plaques, and so only plaques are visible in the right hand image.</p>

Protocol

SDS

COA

Catalog	Size	Price	Quantity
23059	1 g	Price

Citations

View all 14 citations: Citation Explorer

The Molecular Basis of Blood-Brain Barrier Dysfunction and Impaired Neurogenesis in CAA-Related Stroke

Authors:

Osborne, Olivia M

Post-stroke hippocampal neurogenesis is impaired by microvascular dysfunction and PI3K signaling in cerebral amyloid angiopathy

Authors:

Osborne, Olivia M and Daftari, Manav and Naranjo, Oandy and Johar, Adarsh N and Brooks, Samantha and Colbert, Brett M and Torices, Silvia and Lewis, Elizabeth and Sendaydiego, Jet and Drexler, Gillian and others,

Journal:

Cell Reports (2024)

Terahertz Irradiation Improves Cognitive Impairments and Attenuates Alzheimer’s Neuropathology in the APPSWE/PS1DE9 Mouse: A Novel Therapeutic Intervention for Alzheimer’s Disease

Authors:

Zhang, Jun and Chen, Yixin and Zhao, Yarui and Wang, Panpan and Ding, Hongbin and Liu, Cong and Lyu, Junhong and Le, Weidong

Journal:

Neuroscience Bulletin (2023): 1--15

SYK coordinates neuroprotective microglial responses in neurodegenerative disease

Authors:

Ennerfelt, Hannah and Frost, Elizabeth L and Shapiro, Daniel A and Holliday, Coco and Zengeler, Kristine E and Voithofer, Gabrielle and Bolte, Ashley C and Lammert, Catherine R and Kulas, Joshua A and Ulland, Tyler K and others,

Journal:

Cell (2022): 4135--4152

Ube2c-inhibition alleviated amyloid pathology and memory deficits in APP/PS1 mice model of AD

Authors:

Li, Tian and Su, Qiang and Zhang, Zhina and Zhang, Yanli and Yang, Mingxuan and Wang, Zhuoran and Guo, Junhong and Wang, Zhaojun and Wu, Meina and Cai, Hongyan and others,

Journal:

Progress in Neurobiology (2022): 102298

References

View all 28 references: Citation Explorer

Methods for enhancing the accuracy and reproducibility of Congo red and thioflavin T assays

Authors:

Eisert R, Felau L, Brown LR.

Journal:

Anal Biochem (2006): 144

Lipophilic analogs of thioflavin S as novel amyloid-imaging agents

Authors:

Wu C, Cai L, Wei J, Pike VW, Wang Y.

Journal:

Curr Alzheimer Res (2006): 259

Oligo(ethylene glycol) derivatives of Thioflavin T as inhibitors of protein-amyloid interactions

Authors:

Inbar P, Li CQ, Takayama SA, Bautista MR, Yang J.

Journal:

Chembiochem (2006): 1563

Mechanism of thioflavin T accumulation inside cells overexpressing P-glycoprotein or multidrug resistance-associated protein: role of lipophilicity and positive charge

Authors:

Darghal N, Garnier-Suillerot A, Salerno M.

Journal:

Biochem Biophys Res Commun (2006): 623

Characteristics of the binding of thioflavin S to tau paired helical filaments

Authors:

Santa-Maria I, Perez M, Hern and ez F, Avila J, Moreno FJ.

Journal:

J Alzheimers Dis (2006): 279

Physical properties

Molecular weight	N/A
Solvent	DMSO

Spectral properties

Absorbance (nm)	204
Excitation (nm)	391
Emission (nm)	428

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12352200
CAS	1326-12-1

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Page updated on October 15, 2025