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Thioflavin S *CAS 1326-12-1*

The staining of Thioflavin S (in green) on adjacent sections of the hippocampus of a patient suffering from Alzheimer's disease. Thioflavin S binds both senile plaques (SP) and neurofibrillary tangles (NFT), the two characteristic cortical lesions of Alzheimer's. Amyloid beta is a peptide derived from the amyloid precursor protein which is only found in senile plaques, and so only plaques are visible in the right hand image.
The staining of Thioflavin S (in green) on adjacent sections of the hippocampus of a patient suffering from Alzheimer's disease. Thioflavin S binds both senile plaques (SP) and neurofibrillary tangles (NFT), the two characteristic cortical lesions of Alzheimer's. Amyloid beta is a peptide derived from the amyloid precursor protein which is only found in senile plaques, and so only plaques are visible in the right hand image.
The staining of Thioflavin S (in green) on adjacent sections of the hippocampus of a patient suffering from Alzheimer's disease. Thioflavin S binds both senile plaques (SP) and neurofibrillary tangles (NFT), the two characteristic cortical lesions of Alzheimer's. Amyloid beta is a peptide derived from the amyloid precursor protein which is only found in senile plaques, and so only plaques are visible in the right hand image.
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Physical properties
Molecular weightN/A
SolventDMSO
Spectral properties
Absorbance (nm)204
Excitation (nm)391
Emission (nm)428
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
UNSPSC12352200

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CAS
1326-12-1
Molecular weight
N/A
Absorbance (nm)
204
Excitation (nm)
391
Emission (nm)
428
Thioflavin S is a mixture of compounds that results from the methylation of dehydrothiotoluidine with sulphonic acid. It is also used to stain Alzheimer's plaques as ThT.

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Spectral properties

Absorbance (nm)204
Excitation (nm)391
Emission (nm)428

Product Family


NameExcitation (nm)Emission (nm)
Thioflavin T *CAS 2390-54-7*349454

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Citations


View all 12 citations: Citation Explorer
Terahertz Irradiation Improves Cognitive Impairments and Attenuates Alzheimer’s Neuropathology in the APPSWE/PS1DE9 Mouse: A Novel Therapeutic Intervention for Alzheimer’s Disease
Authors: Zhang, Jun and Chen, Yixin and Zhao, Yarui and Wang, Panpan and Ding, Hongbin and Liu, Cong and Lyu, Junhong and Le, Weidong
Journal: Neuroscience Bulletin (2023): 1--15
Ube2c-inhibition alleviated amyloid pathology and memory deficits in APP/PS1 mice model of AD
Authors: Li, Tian and Su, Qiang and Zhang, Zhina and Zhang, Yanli and Yang, Mingxuan and Wang, Zhuoran and Guo, Junhong and Wang, Zhaojun and Wu, Meina and Cai, Hongyan and others,
Journal: Progress in Neurobiology (2022): 102298
SYK coordinates neuroprotective microglial responses in neurodegenerative disease
Authors: Ennerfelt, Hannah and Frost, Elizabeth L and Shapiro, Daniel A and Holliday, Coco and Zengeler, Kristine E and Voithofer, Gabrielle and Bolte, Ashley C and Lammert, Catherine R and Kulas, Joshua A and Ulland, Tyler K and others,
Journal: Cell (2022): 4135--4152
Trichostatin A ameliorates Alzheimer's disease-related pathology and cognitive deficits by increasing albumin expression and A$\beta$ clearance in APP/PS1 mice
Authors: Su, Qiang and Li, Tian and He, Pei-Feng and Lu, Xue-Chun and Yu, Qi and Gao, Qi-Chao and Wang, Zhao-Jun and Wu, Mei-Na and Yang, Dan and Qi, Jin-Shun
Journal: Alzheimer's Research \& Therapy (2021): 1--15
Human Telomeric Hybrid-2-over-Hybrid-1 G-quadruplex Targeting and a Selective Hypersaline-Tolerant Sensor Using Abasic Site-Engineered Monomorphism
Authors: Wu, Tao and Ye, Meiyun and Mao, Tianyi and Lin, Fan and Hu, Yuehua and Gan, Ning and Shao, Yong
Journal: Analytica Chimica Acta (2017)
Fluorescent dyes in the context of DNA-binding: The case of Thioflavin T
Authors: Biancardi, Aless and ro , undefined and Biver, Tarita and Mennucci, Benedetta
Journal: International Journal of Quantum Chemistry (2017)
Thioflavin T as a fluorescence probe for monitoring RNA metabolism at molecular and cellular levels
Authors: Sugimoto, Shinya and Arita-Morioka, Ken-ichi and Mizunoe, Yoshimitsu and Yamanaka, Kunitoshi and Ogura, Teru
Journal: Nucleic acids research (2015): gkv338
Determinants of amyloid fibril degradation by the PDZ protease HTRA1
Authors: Poepsel, Simon and Sprengel, Andreas and Sacca, Barbara and Kaschani, Farnusch and Kaiser, Markus and Gatsogiannis, Christos and Raunser, Stefan and Clausen, Tim and Ehrmann, Michael
Journal: Nature chemical biology (2015): 862--869
Mechanistic aspects of thioflavin-T self-aggregation and DNA binding: evidence for dimer attack on DNA grooves
Authors: Biancardi, A and Biver, T and Burgalassi, A and Mattonai, M and Secco, F and Venturini, M
Journal: Physical Chemistry Chemical Physics (2014): 20061--20072
Molecular rotor-based fluorescent probe for selective recognition of hybrid G-quadruplex and as a K+ sensor
Authors: Liu, Lingling and Shao, Yong and Peng, Jian and Huang, Chaobiao and Liu, Hua and Zhang, Lihua
Journal: Analytical chemistry (2014): 1622--1631

References


View all 28 references: Citation Explorer
Methods for enhancing the accuracy and reproducibility of Congo red and thioflavin T assays
Authors: Eisert R, Felau L, Brown LR.
Journal: Anal Biochem (2006): 144
Lipophilic analogs of thioflavin S as novel amyloid-imaging agents
Authors: Wu C, Cai L, Wei J, Pike VW, Wang Y.
Journal: Curr Alzheimer Res (2006): 259
Oligo(ethylene glycol) derivatives of Thioflavin T as inhibitors of protein-amyloid interactions
Authors: Inbar P, Li CQ, Takayama SA, Bautista MR, Yang J.
Journal: Chembiochem (2006): 1563
Mechanism of thioflavin T accumulation inside cells overexpressing P-glycoprotein or multidrug resistance-associated protein: role of lipophilicity and positive charge
Authors: Darghal N, Garnier-Suillerot A, Salerno M.
Journal: Biochem Biophys Res Commun (2006): 623
Characteristics of the binding of thioflavin S to tau paired helical filaments
Authors: Santa-Maria I, Perez M, Hern and ez F, Avila J, Moreno FJ.
Journal: J Alzheimers Dis (2006): 279
Efficient radiosynthesis of carbon-11 labelled uncharged Thioflavin T derivatives using [11C]methyl triflate for beta-amyloid imaging in Alzheimer's Disease with PET
Authors: Solbach C, Uebele M, Reischl G, Machulla HJ.
Journal: Appl Radiat Isot (2005): 591
Chiral bias of amyloid fibrils revealed by the twisted conformation of Thioflavin T: an induced circular dichroism/DFT study
Authors: Dzwolak W, Pecul M.
Journal: FEBS Lett (2005): 6601
Development of novel amyloid imaging agents based upon thioflavin S
Authors: Wei J, Wu C, Lankin D, Gulrati A, Valyi-Nagy T, Cochran E, Pike VW, Kozikowski A, Wang Y.
Journal: Curr Alzheimer Res (2005): 109
The binding of thioflavin-T to amyloid fibrils: localisation and implications
Authors: Krebs MR, Bromley EH, Donald AM.
Journal: J Struct Biol (2005): 30
Mechanism of thioflavin T binding to amyloid fibrils
Authors: Khurana R, Coleman C, Ionescu-Zanetti C, Carter SA, Krishna V, Grover RK, Roy R, Singh S.
Journal: J Struct Biol (2005): 229