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Tide Quencher™ 1 CPG
TQ1 CPG; 500 Å
TQ1 is designed to be a superior quencher alternative to DABCYL. Compared to DABCYL, TQ1 have (a). much stronger absorption; (b). much higher quenching efficiency; and (c). versatile reactive forms with desired solubility for labeling oligonucleotides and peptides. This TQ1 product is primarily used for the in-synthesis labeling of oligonucleotides.
<p style="background: white; margin: 6.0pt 0in 6.0pt 0in;"><span style="font-size: 10.0pt;">Oligonucleotide synthesis is carried out by a stepwise addition of nucleotide residues to the 5'-terminus of the growing chain until the desired sequence is assembled. Each addition is referred to as a synthetic cycle and consists of four chemical reactions: d<span class="mw-headline">e-blocking (detritylation)</span><span style="user-select: none; display: inline-block; unicode-bidi: isolate;">, coupling</span><span style="user-select: none; display: inline-block; unicode-bidi: isolate;">, capping</span><span style="user-select: none; display: inline-block; unicode-bidi: isolate;">, and oxidation</span><span style="user-select: none; display: inline-block; unicode-bidi: isolate;">.</span></span></p>
<p style="background: white; margin: 6.0pt 0in 6.0pt 0in;"><span style="font-size: 10.0pt;">Oligonucleotide synthesis is carried out by a stepwise addition of nucleotide residues to the 5'-terminus of the growing chain until the desired sequence is assembled. Each addition is referred to as a synthetic cycle and consists of four chemical reactions: d<span class="mw-headline">e-blocking (detritylation)</span><span style="user-select: none; display: inline-block; unicode-bidi: isolate;">, coupling</span><span style="user-select: none; display: inline-block; unicode-bidi: isolate;">, capping</span><span style="user-select: none; display: inline-block; unicode-bidi: isolate;">, and oxidation</span><span style="user-select: none; display: inline-block; unicode-bidi: isolate;">.</span></span></p>
protocol
Protocol
sds
SDS
COA
CatalogSize
Price
Quantity
2193100 mg
Price
 
Physical properties
Molecular weightN/A
SolventMeCN
Spectral properties
Absorbance (nm)492
Correction factor (260 nm)0.147
Correction factor (280 nm)0.194
Extinction coefficient (cm -1 M -1)
20000
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
UNSPSC12352200
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Page updated on October 12, 2025