Tide Quencher™ 7.1WS maleimide [TQ7.1WS maleimide]
Ordering information
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Additional ordering information
Telephone | 1-800-990-8053 |
Fax | 1-800-609-2943 |
sales@aatbio.com | |
International | See distributors |
Bulk request | Inquire |
Custom size | Inquire |
Shipping | Standard overnight for United States, inquire for international |
Physical properties
Molecular weight | 1100.16 |
Solvent | DMSO |
Storage, safety and handling
H-phrase | H303, H313, H333 |
Hazard symbol | XN |
Intended use | Research Use Only (RUO) |
R-phrase | R20, R21, R22 |
Storage | Freeze (< -15 °C); Minimize light exposure |
Alternative formats
Tide Quencher™ 7.1WS amine [TQ7.1WS amine] |
Tide Quencher™ 7.1WS acid [TQ7.1WS acid] |
Tide Quencher™ 7.1WS azide [TQ7.1WS azide] |
Tide Quencher™ 7.1WS alkyne [TQ7.1WS alkyne] |
Related products
Overview | ![]() ![]() |
See also: Tide Quencher Dyes
Molecular weight 1100.16 |
Tide Quencher™ 7.1WS (TQ7.1WS) is a non-fluorescent molecule designed to efficiently quench the fluorescence of common NIR fluorophores such as Cy7, Alexa Fluor® 700, Alexa Fluor® 750, iFluor® 700, iFluor® 710, iFluor® 720 and iFluor® 750. It is an improved version of TQ7 and BHQ3. TQ7.1WS is designed to be a superior quencher with (a). much stronger absorption, and (b). much higher quenching efficiency for NIR dyes. Tide Quencher™ 7.1WS maleimide is primarily used for the post-labeling of thiol-modified oligonucleotides and the Cys residues of peptides. It can be used in techniques such as polymerase chain reaction (PCR), real-time PCR, and DNA sequencing. In these applications, fluorescence signals are used to monitor the amplification or detection of specific DNA sequences. TQ7.1WS quenches the fluorescent signal until a specific event (like DNA strand separation or primer extension) occurs, leading to an increase in fluorescence that can be detected and quantified. Fluorescence resonance energy transfer (FRET)-based assays are widely used to detect and measure the presence of specific molecules in a sample. They involve the use of a fluorescent molecule (fluorophore) and a quencher molecule such as TQ7.1WS. The fluorophore emits light when excited by a specific wavelength of light, while the quencher molecule absorbs this emitted light, effectively "quenching" the fluorescence signal.
Calculators
Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of Tide Quencher™ 7.1WS maleimide [TQ7.1WS maleimide] to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
1 mM | 90.896 µL | 454.479 µL | 908.959 µL | 4.545 mL | 9.09 mL |
5 mM | 18.179 µL | 90.896 µL | 181.792 µL | 908.959 µL | 1.818 mL |
10 mM | 9.09 µL | 45.448 µL | 90.896 µL | 454.479 µL | 908.959 µL |
Molarity calculator
Enter any two values (mass, volume, concentration) to calculate the third.
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References
View all 36 references: Citation Explorer
PEGylated and Non-PEGylated TCP-1 Probes for Imaging of Colorectal Cancer.
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Signal Amplification Pretargeted PET/Fluorescence Imaging Based on Human Serum Albumin-Encapsulated GdF3 Nanoparticles for Diagnosis of Ovarian Cancer.
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99mTechnetium- or Cy7-Labeled Fab(Tocilizumab) as Potential Multiple Myeloma Imaging Agents.
Authors: Camacho, Ximena and Perroni, Carolina and Machado, Camila L and de Godoi Carneiro, Camila and de Souza Junqueira, Mara and Faria, Daniele and García, María F and Fernández, Marcelo and Oddone, Natalia and Benech, Juan and Buchpiguel, Carlos A and Cerecetto, Hugo and Chammas, Roger and Riva, Eloisa and Cabral, Pablo and Gambini, Juan P
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Authors: Camacho, Ximena and Perroni, Carolina and Machado, Camila L and de Godoi Carneiro, Camila and de Souza Junqueira, Mara and Faria, Daniele and García, María F and Fernández, Marcelo and Oddone, Natalia and Benech, Juan and Buchpiguel, Carlos A and Cerecetto, Hugo and Chammas, Roger and Riva, Eloisa and Cabral, Pablo and Gambini, Juan P
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Fluorescence and ratiometric photoacoustic imaging of endogenous furin activity via peptide functionalized MoS2 nanosheets.
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Enabling In Vivo Photocatalytic Activation of Rapid Bioorthogonal Chemistry by Repurposing Silicon-Rhodamine Fluorophores as Cytocompatible Far-Red Photocatalysts.
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Journal: Journal of the American Chemical Society (2021): 10793-10803
Authors: Wang, Chuanqi and Zhang, He and Zhang, Tao and Zou, Xiaoyu and Wang, Hui and Rosenberger, Julia E and Vannam, Raghu and Trout, William S and Grimm, Jonathan B and Lavis, Luke D and Thorpe, Colin and Jia, Xinqiao and Li, Zibo and Fox, Joseph M
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In Vitro and In Vivo Studies on HPMA-Based Polymeric Micelles Loaded with Curcumin.
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Investigation of the Transport Pathways Associated with Enhanced Brain Delivery of Peptide Drugs by Intranasal Coadministration with Penetratin.
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