TMA-DPH *CAS#: 115534-33-3*

TMA-DPH

CAS#: 115534-33-3

TMA-DPH is a fluorescent probe for membrane fluidity measurements. It is especially useful in the study of monolayer dynamics of lipoproteins and similar analogous systems. DPH and its derivatives (such as TMA-DPH) are cylinder-shaped and have fluorescence emission transition dipoles that are basically aligned parallel to their long molecular axis. As such, they are very sensitive to reorientation resulting from interactions with surrounding lipids. They are widely used in fluorescence polarization studies of rotational motion.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
21492	5 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of TMA-DPH *CAS#: 115534-33-3* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	216.628 µL	1.083 mL	2.166 mL	10.831 mL	21.663 mL
5 mM	43.326 µL	216.628 µL	433.257 µL	2.166 mL	4.333 mL
10 mM	21.663 µL	108.314 µL	216.628 µL	1.083 mL	2.166 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	461.62 g/mol	=	mL	x	mM	=	mmol

Citations

View all 10 citations: Citation Explorer

Toxicity of hexagonal boron nitride nanosheets to freshwater algae: Phospholipid membrane damage and carbon assimilation inhibition

Authors:

Zou, Wei and Huo, Yuhan and Zhang, Xingli and Jin, Caixia and Li, Xiaokang and Cao, Zhiguo

Journal:

Journal of Hazardous Materials (2023): 133204

Cis-and trans-variations of Stearoyl-CoA Desaturase Provide New Insights into the Mechanisms of Diverged Pattern of Phenotypic Plasticity for Temperature Adaptation in Two Congeneric Oyster Species

Authors:

Wang, Chaogang and Li, Ao and Cong, Rihao and Qi, Haigang and Wang, Wei and Zhang, Guofan and Li, Li

Journal:

Molecular Biology and Evolution (2023)

Size-dependent effects of polystyrene microplastics on cytotoxicity and efflux pump inhibition in human Caco-2 cells

Authors:

Wu, Bing and Wu, Xiaomei and Liu, Su and Wang, Zhizhi and Chen, Ling

Journal:

Chemosphere (2019)

Comparison of cytotoxicity and membrane efflux pump inhibition in HepG2 cells induced by single-walled carbon nanotubes with different length and functional groups

Authors:

Shen, Zhuoyan and Wu, Jialu and Yu, Yue and Liu, Su and Jiang, Wei and Nurmamat, Habiba and Wu, Bing

Journal:

Scientific Reports (2019): 7557

Interaction of Hsp90 with phospholipid model membranes

Authors:

Zhang, Muhan and Wang, Daoying and Li, Pengpeng and Sun, Chong and Xu, Rong and Geng, Zhiming and Xu, Weimin and Dai, Zhaoqi

Journal:

Biochimica et Biophysica Acta (BBA)-Biomembranes (2018): 611--616

References

View all 16 references: Citation Explorer

Fluorescent probes DPH, TMA-DPH and C17-HC induce erythrocyte exovesiculation

Authors:

Saldanha C, Santos NC, Martins-Silva J.

Journal:

J Membr Biol (2002): 75

Fluorescent lipid probes 12-AS and TMA-DPH report on selective, purinergically induced fluidity changes in plasma membranes of lymphoid cells

Authors:

Matko J, Nagy P.

Journal:

J Photochem Photobiol B (1997): 120

Plasma membrane fluidity of keratinocytes of normal and psoriatic skin: a study using fluorescence anisotropy of trimethylammoniumdiphenylhexatriene (TMA-DPH)

Authors:

Simonetti O, Ferretti G, Offidani AM, Gervasi P, Curatola G, Bossi G.

Journal:

Arch Dermatol Res (1996): 51

Enzymically generated electron-excited species increase the membrane order parameter without changing the rotational relaxation time of TMA-DPH

Authors:

Obsil T, Amler E, Kotyk A, Pavlicek Z.

Journal:

Gen Physiol Biophys (1995): 393

A comparison of the fluorescence properties of TMA-DPH as a probe for plasma membrane and for endocytic membrane

Authors:

Illinger D, Duportail G, Mely Y, Poirel-Morales N, Gerard D, Kuhry JG.

Journal:

Biochim Biophys Acta (1995): 58

Physical properties

Molecular weight	461.62
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12352200
CAS	115534-33-3

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Page updated on October 13, 2025