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Z-VEID-FMK
Z-VEID-FMK is a cell permeable inhibitor of caspase 6. It irreversibly binds to active caspase 6. Caspases 3, 7 and 8 might also bind to Z-VEID-FMK, but much less efficiently than caspase 6. Apoptosis is an evolutionarily conserved form of cell suicide, which follows a specialized cellular process. The central component of the apoptosis process is a cascade of proteolytic enzymes called caspases. These enzymes participate in a series of reactions that are triggered in response to pro-apoptotic signals and result in cleavage of protein substrates, causing the disassembly of the cell. Caspases have been identified in organisms ranging from C. elegans to humans. The mammalian caspases play distinct roles in apoptosis and inflammation. In apoptosis, caspases are responsible for proteolytic cleavages that lead to cell disassembly (effector caspases) and are involved in upstream regulatory events (initiator caspases). An active caspase consists of two large (~20 kD) and two small (~10 kD) subunits to form two heterodimers which associate in a tetramer.
References
View all 50 references: Citation Explorer
Organoselenium-based Azomethines as Apoptosis Inducers in Colorectal Carcinoma via P53, BAX, Caspase-3, Caspase-6, and Caspase-9 Modulations.
Authors: Shaaban, Saad and Hammouda, Mohamed M and Althikrallah, Hanan A and Al Nawah, Jawaher Y and Ba-Ghazal, Hussein and Sharaky, Marwa and Abulkhair, Hamada S and Al-Karmalawy, Ahmed A
Journal: Current medicinal chemistry (2024)
Authors: Shaaban, Saad and Hammouda, Mohamed M and Althikrallah, Hanan A and Al Nawah, Jawaher Y and Ba-Ghazal, Hussein and Sharaky, Marwa and Abulkhair, Hamada S and Al-Karmalawy, Ahmed A
Journal: Current medicinal chemistry (2024)
Knocking down macrophages Caspase-6 through HMGB1 coordinates macrophage trophoblast crosstalk to suppress ferroptosis and alleviate preeclampsia.
Authors: Deng, Yali and Yu, Ling and Lai, Weisi and Xiao, Songyuan and Zhang, Wen
Journal: International immunopharmacology (2024): 112859
Authors: Deng, Yali and Yu, Ling and Lai, Weisi and Xiao, Songyuan and Zhang, Wen
Journal: International immunopharmacology (2024): 112859
Spinal Caspase-6 Contributes to Intrathecal Morphine-induced Acute Itch and Contact Dermatitis-induced Chronic Itch Through Regulating the Phosphorylation of Protein Kinase Mζ in Mice.
Authors: Pei, Xuxing and Li, Bing and Xu, Xiaodong and Zhang, Hui
Journal: Neuroscience (2024): 21-34
Authors: Pei, Xuxing and Li, Bing and Xu, Xiaodong and Zhang, Hui
Journal: Neuroscience (2024): 21-34
Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice.
Authors: Kuijper, Elsa C and Overzier, Maurice and Suidgeest, Ernst and Dzyubachyk, Oleh and Maguin, Cécile and Pérot, Jean-Baptiste and Flament, Julien and Ariyurek, Yavuz and Mei, Hailiang and Buijsen, Ronald A M and van der Weerd, Louise and van Roon-Mom, Willeke
Journal: Neurobiology of disease (2024): 106368
Authors: Kuijper, Elsa C and Overzier, Maurice and Suidgeest, Ernst and Dzyubachyk, Oleh and Maguin, Cécile and Pérot, Jean-Baptiste and Flament, Julien and Ariyurek, Yavuz and Mei, Hailiang and Buijsen, Ronald A M and van der Weerd, Louise and van Roon-Mom, Willeke
Journal: Neurobiology of disease (2024): 106368
NUAK1 promotes metabolic dysfunction-associated steatohepatitis progression by activating Caspase 6-driven pyroptosis and inflammation.
Authors: Sheng, Mingwei and Huo, Shuhan and Jia, Lili and Weng, Yiqi and Liu, Weihua and Lin, Yuanbang and Yu, Wenli
Journal: Hepatology communications (2024)
Authors: Sheng, Mingwei and Huo, Shuhan and Jia, Lili and Weng, Yiqi and Liu, Weihua and Lin, Yuanbang and Yu, Wenli
Journal: Hepatology communications (2024)
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