Zinquin *CAS#: 151606-29-0*

Zinquin

CAS#: 151606-29-0

Zinquin is a zinc-sensitive, cell-impermeable fluorescent probe. Zinc is the second most abundant transition metal in the body and it is essential as catalytic, structural and regulatory ion. Zinc ions are involved in homeostasis, immune responses, oxidative stress, apoptosis and aging. Zinc has been proposed to function as a conventional neurotransmitter for the presynaptic neuron and as a transmembrane signal to traverse the postsynaptic neuron. Aberrant zinc metabolism is associated with many neurological diseases including Alzheimer's disease, Parkinson's disease and epilepsy. The most suitable technique for in vivo monitoring of zinc has been proven to be fluorescence imaging.

Catalog	Size	Price	Quantity
21260	5 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Zinquin *CAS#: 151606-29-0* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	258.786 µL	1.294 mL	2.588 mL	12.939 mL	25.879 mL
5 mM	51.757 µL	258.786 µL	517.572 µL	2.588 mL	5.176 mL
10 mM	25.879 µL	129.393 µL	258.786 µL	1.294 mL	2.588 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	386.42 g/mol	=	mL	x	mM	=	mmol

References

View all 8 references: Citation Explorer

Zinquin identifies subcellular compartmentalization of zinc in cortical neurons. Relation to the trafficking of zinc and the mitochondrial compartment

Authors:

Colvin RA, Laskowski M, Fontaine CP.

Journal:

Brain Res (2006): 1

S-Nitroso compounds interfere with zinc probing by Zinquin

Authors:

Jansen S, Arning J, Dulcks T, Beyersmann D.

Journal:

Anal Biochem (2004): 145

Coordination and fluorescence of the intracellular Zn2+ probe [2-methyl-8-(4-toluenesulfonamido)-6-quinolyloxy]acetic acid (Zinquin A) in ternary Zn2+ complexes

Authors:

Hendrickson KM, Geue JP, Wyness O, Lincoln SF, Ward AD.

Journal:

J Am Chem Soc (2003): 3889

Fluorescent detection of Zn(2+)-rich vesicles with Zinquin: mechanism of action in lipid environments

Authors:

Snitsarev V, Budde T, Stricker TP, Cox JM, Krupa DJ, Geng L, Kay AR.

Journal:

Biophys J (2001): 1538

The synthesis and fluorescent properties of analogues of the zinc(II) specific fluorophore zinquin ester

Authors:

Kimber MC, Mahadevan IB, Lincoln SF, Ward AD, Tiekink ER.

Journal:

J Org Chem (2000): 8204

Physical properties

Molecular weight	386.42
Solvent	DMSO

Spectral properties

Excitation (nm)	355
Emission (nm)	491

Storage, safety and handling

Certificate of Origin	Download PDF
H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12352200
CAS	151606-29-0

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