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Zinquin *CAS#: 151606-29-0*

Zinquin is a zinc-sensitive, cell-impermeable fluorescent probe. Zinc is the second most abundant transition metal in the body and it is essential as catalytic, structural and regulatory ion. Zinc ions are involved in homeostasis, immune responses, oxidative stress, apoptosis and aging. Zinc has been proposed to function as a conventional neurotransmitter for the presynaptic neuron and as a transmembrane signal to traverse the postsynaptic neuron. Aberrant zinc metabolism is associated with many neurological diseases including Alzheimer's disease, Parkinson's disease and epilepsy. The most suitable technique for in vivo monitoring of zinc has been proven to be fluorescence imaging.

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Zinquin *CAS#: 151606-29-0* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM258.786 µL1.294 mL2.588 mL12.939 mL25.879 mL
5 mM51.757 µL258.786 µL517.572 µL2.588 mL5.176 mL
10 mM25.879 µL129.393 µL258.786 µL1.294 mL2.588 mL

Molarity calculator

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Spectrum

Citations

View all 1 citations: Citation Explorer
Biomimetic Nano-Immunoactivator via Ionic Metabolic Modulation for Strengthened NIR-II Photothermal Immunotherapy
Authors: Wei, Xiaodan and Huang, Honglin and Guo, Junhan and Li, Ningxi and Li, Qingzhi and Zhao, Tian and Yang, Geng and Cai, Lulu and Yang, Hong and Wu, Chunhui and others,
Journal: Small (2023): 2304370

References

View all 8 references: Citation Explorer
Zinquin identifies subcellular compartmentalization of zinc in cortical neurons. Relation to the trafficking of zinc and the mitochondrial compartment
Authors: Colvin RA, Laskowski M, Fontaine CP.
Journal: Brain Res (2006): 1
S-Nitroso compounds interfere with zinc probing by Zinquin
Authors: Jansen S, Arning J, Dulcks T, Beyersmann D.
Journal: Anal Biochem (2004): 145
Coordination and fluorescence of the intracellular Zn2+ probe [2-methyl-8-(4-toluenesulfonamido)-6-quinolyloxy]acetic acid (Zinquin A) in ternary Zn2+ complexes
Authors: Hendrickson KM, Geue JP, Wyness O, Lincoln SF, Ward AD.
Journal: J Am Chem Soc (2003): 3889
Fluorescent detection of Zn(2+)-rich vesicles with Zinquin: mechanism of action in lipid environments
Authors: Snitsarev V, Budde T, Stricker TP, Cox JM, Krupa DJ, Geng L, Kay AR.
Journal: Biophys J (2001): 1538
The synthesis and fluorescent properties of analogues of the zinc(II) specific fluorophore zinquin ester
Authors: Kimber MC, Mahadevan IB, Lincoln SF, Ward AD, Tiekink ER.
Journal: J Org Chem (2000): 8204
Page updated on November 9, 2024

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Physical properties

Molecular weight

386.42

Solvent

DMSO

Spectral properties

Excitation (nm)

355

Emission (nm)

491

Storage, safety and handling

Certificate of OriginDownload PDF
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22

Storage

Freeze (< -15 °C); Minimize light exposure
UNSPSC12352200

CAS

151606-29-0
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