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Is there a good antibody available to detect C-terminal fragments of amyloid precursor protein (APP)?
Posted April 24, 2020
Antibodies and Proteomics BioconjugationAntibody and Protein LabelingIHCImmunohistochemistry (IHC)
Answer

A great option is to use Y188, which is a rabbit monoclonal antibody that recognizes the C-terminus of amyloid precursor protein with high specificity.

Additional resources
Guo, Q., Li, H., Gaddam, S.S., Justice, N.J., Robertson, C.S., & Zheng, H. (2011). Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives. Journal of biological chemistry, 287(4), 2437-2445. doi: 10.1074/jbc.M111.315051

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