What is the difference between M1 and M2 macrophages and how can you differentiate them?

M1 macrophages are seen to be involved in pro-inflammatory and immune responses. CD80, CD86, iNOS, and MHC-II are all markers that can be used to identify M1 macrophages.

Meanwhile, M2 macrophages are involved with cell proliferation and tissue repair, and can be identified by cell surface markers CD206, CD209, and CD163.