One key advantage is that colloidal Coomassie offers higher sensitivity compared to traditional Coomassie staining, allowing for the detection of low-abundance proteins. Another pro is that the staining process is straightforward and does not require complex procedures, making it relatively easy to perform. Additionally, Colloidal Coomassie stains can be prepared to stain proteins effectively within 1 hour and only need water, eliminating the need for methanol or acetic acid. It also offers high reproducibility and background staining is reduced.