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What are the common features of amyloids?
Posted July 11, 2024
Antibodies and Proteomics Chemical ReagentsCellular Structures and OrganellesImmunohistochemistry (IHC)Physiological Probes
Answer

Common features of amyloids include: 

  • Fibrillar appearance on electron micrography
  • X-ray diffraction pattern reveals beta-pleated sheet structure
  • Histological staining with Congo red results in apple-green birefringence 
  • Hematoxylin and eosin staining reveal amorphous eosinophilic appearance
  • Soluble in waters and buffers of low ionic strength 
Additional resources
Amyloid Structure: Conformational Diversity and Consequences Neurodegeneration & Amyloid Staining Congo Red *UltraPure grade* *CAS 573-58-0*

What causes amyloid?What are the staining methods for identifying amyloid in tissue sections?What is Congo Red?What is metachromasia?What are amyloids?