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What are the differences between Epidermis and Dermis?
Posted September 5, 2023

Answer

Basis of differentiation

Epidermis

Dermis

Definition
Epidermis is the outer layer of cells, which cover the body of an organism
Dermis is a thick layer of living cells below the epidermis, containing blood vessels, sweat glands, hair follicles, and nerve endings
Depth and thickness
Is the superficial, thin cell layer
Is the thickest layer of skin, and deeper than the epidermis
Presence of cells
Contain both living and dead cells
All cells are living cells
Presence of blood vessels
Epidermis does not contain blood vessels
Dermis has an extensive network of blood vessels
Origin
Originates from the ectoderm
Originates from the mesoderm
Components
Consists of keratin in humans and suberin in plants
Consists of hair follicles, nails, sweat glands, and apocrine glands
Structure
Is made up of stratified layers of flattened epithelial cells
Is made up of dense irregular connective tissue
Presence of ECM
Contains tightly packed cells without an ECM
Contains an ECM
Presence of nerves
No nerve receptors are present in the epidermis
Has sensory nerve endings present
Mechanism of obtaining nutrients
Obtains essential nutrients and oxygen by diffusion from the dermis
Obtains oxygen and nutrients from the blood capillaries 
Cell types 
Contains melanocytes, langerhans cells, merkel's cells, and keratinocytes
Contains fibroblasts, macrophages, and adipocytes