Basis of differentiation

Ion exchange chromatography

Ion pair chromatography 

Definition

Is a form of liquid chromatography to separate organic and inorganic molecules

Is a technique in which ions in a sample are paired and separated as ion pairs

Stationary Phase

Contains charged functional groups (anion or cation exchange resins)

Typically nonpolar reversed-phase columns

Reproducibility

Low

Very high

Separation time

High

Low

Separation mechanism

Ion exchange between sample ions and stationary phase

Formation of ion pairs between sample ions and ion pairing reagent