CD24 a sialoglycoprotein that helps to modulate cell growth, differentiation, and autoimmunity. A mature CD24 protein consists of 32 amino acids that is anchored via a glycosyl phosphatidylinositol link to the cell surface that encourages downstream signaling. CD24 also modulates B-cell activation responses, promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. It has been found recently that CD24 on tumor cells was identified as a phagocytic inhibitor, releasing a “do not eat me” signal, and has a suppressive role in tumor immunity via binding to Siglec-10 on macrophages. Diseases associated with CD24 dysfunction include erythroleukemia and bile duct cancer.
Common detection and quantitative analysis methods include IHC techniques, Western Blot, flow cytometry, rt-PCR, and statistical tests. CD24 is highly studies in cancer research.
Cell Types
- Granulocytes
- B cells
- T cells
- Many cancerous cell types
- Antigen Presenting Cells (APCs)
- Hematopoietic cells
- Neutrophils
- Eosinophils
- Dendritic cells
- Macrophages
- Neural cells
- Ganglion cells
- Epithelia cells
- Keratinocytes
- Muscle cells
Reference
- Barkal, A. A., Brewer, R. E., Markovic, M., Kowarsky, M., Barkal, S. A., Zaro, B. W., Krishnan, V., Hatakeyama, J., Dorigo, O., Barkal, L. J., & Weissman, I. L. (2019). CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy. Nature, 572(7769), 392–396. https://doi.org/10.1038/s41586-019-1456-0