GLG1 (Golgi glycoprotein 1) GLG1 is primarily known as an E-selectin ligand that mediates the initial step of tethering and rolling of leukocytes on vascular endothelium, however also enables fibroblast growth factor binding activity withing the Golgi apparatus. GLG1 functions through several processes including negative regulation of protein processing, negative regulation of transforming growth factor beta receptor signaling pathway, and regulation of chondrocyte differentiation. Diseases associated with GLG1 include amyotrophic lateral sclerosis 1, though GLG1 may play a role in circulating tumor cells, and facilitate arrest and extravasation into adjacent tissues.
Some detection and analytical techniques include IHC, co-immunoprecipitation, Western Blot, Northern blot, rt-PCR, immunofluorescence and confocal microscopy, selective PAS methods for glycoprotein detection, NGS, and statistical analysis.