What is Leptin?

Leptin is a hormone secreted by white adipocytes. It plays a significant role in regulating energy homeostasis, metabolism, and body weight control. Leptin binds to the receptors in the brain and many other tissues, which influence downstream signaling pathways that inhibit feeding and promote energy expenditure. Leptin also has several endocrine functions and regulates immune and inflammatory responses, hematopoiesis, angiogenesis, reproduction, bone formation, and wound healing. Leptin dysfunction is related to severe obesity, morbid obesity with hypogonadism, type 2 diabetes mellitus, and eating disorders.

Common detection and analytical techniques include ELISA, Alpha-LISA, Western Blot, radioimmunoassay, IHC, FISH, RNA analysis, rt-PCR, and statistical analysis.

Cell Types

• Adipocytes
• Neural stem cells
• Mesenchymal stromal cells
• Pancreatic beta-cells

Reference

1. Zhou, Y., & Rui, L. (2013). Leptin signaling and leptin resistance. Frontiers of medicine, 7(2), 207–222. https://doi.org/10.1007/s11684-013-0263-5