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What type of antigen is present in the Major Histocompatibility Complex (MHC)?
Posted August 26, 2024
Antibodies and Proteomics Bioconjugation Chemical ReagentsCell SignalingCellular ProcessesImmunohistochemistry (IHC)Physiological Probes
Answer
The Human Leukocyte Antigen (HLA) is the one type of antigen present in the Major Histocompatibility Complex (MHC). It plays a crucial role in the MHC’s function.
There are various types of HLA present in MHC Class I and MHC Class II.
- The three types of HLAs present in MHC Class I are HLA-A, HLA-B and HLA-C.
- The three types of HLAs present in MHC Class II are HLA-DR, HLA-DQ, and HLA-DP.
HLA is responsible for identifying foreign substances within the body. It first detects whether a substance is foreign. If the substance originates from the body, the appropriate HLA signals MHC Class I. If the substance is a foreign antigen that has not originated from the body, the HLA signals MHC Class II, triggering an immune response.