Aspartame Toxicity (LD50)

The median lethal dose (LD50) for Aspartame is

10000 mg

per

*Value is measured via oral route in mice

Compound Information

Aspartame (Also known as: Nutrasweet, Asp-Phe Methyl Ester) is a dipeptide obtained by formal condensation of the alpha-carboxy group of L-aspartic acid with the amino group of methyl L-phenylalaninate. It is commonly used as an artificial sweetener. It also has roles as a nutraceutical, a micronutrient, a xenobiotic, an environmental contaminant, an apoptosis inhibitor and an EC 3.1.3.1 (alkaline phosphatase) inhibitor. It is a dipeptide, a carboxylic acid and a methyl ester. Chemically, it derives from a L-aspartic acid and a methyl L-phenylalaninate.

Molecular weight: 294.3Chemical formula: C₁₄H₁₈N₂O₅

Information presented on this page is purely for research purposes only. It is NOT intended for clinical or diagnostic applications. To request additional information and datasets for Aspartame, please contact info@aatbio.com.

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References

This online resource may be cited as follows

MLA	"Quest Database™ Aspartame Toxicity (LD50)." AAT Bioquest, Inc., 20 Sep. 2025, https://www.aatbio.com/resources/toxicity-lethality-median-dose-td50-ld50/aspartame.
APA	AAT Bioquest, Inc. (2025, September 20). Quest Database™ Aspartame Toxicity (LD50). AAT Bioquest. https://www.aatbio.com/resources/toxicity-lethality-median-dose-td50-ld50/aspartame.
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