Nicotine Toxicity (LD50)

The median lethal dose (LD50) for Nicotine is

0.8 mg

per

*Value is measured via oral route in rat

Compound Information

Nicotine (Also known as: L-Nicotine, (-)-Nicotine, (S)-Nicotine) is a plant alkaloid, found in the tobacco plant, and addictive central nervous system (CNS) stimulant that causes either ganglionic stimulation in low doses or ganglionic blockage in high doses. It is a teratogen (capable of causing birth defects), and suspected carcinogen. Nicotine can be absorbed into the body by inhalation, ingestion, skin contact, and mucous membranes.

Molecular weight: 162.23Chemical formula: C₁₀H₁₄N₂

Information presented on this page is purely for research purposes only. It is NOT intended for clinical or diagnostic applications. To request additional information and datasets for Nicotine, please contact info@aatbio.com.

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References

This online resource may be cited as follows

MLA	"Quest Database™ Nicotine Toxicity (LD50)." AAT Bioquest, Inc., 17 Oct. 2025, https://www.aatbio.com/resources/toxicity-lethality-median-dose-td50-ld50/nicotine.
APA	AAT Bioquest, Inc. (2025, October 17). Quest Database™ Nicotine Toxicity (LD50). AAT Bioquest. https://www.aatbio.com/resources/toxicity-lethality-median-dose-td50-ld50/nicotine.
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