Psilocybin Toxicity (LD50)

The median lethal dose (LD50) for Psilocybin is

280 mg

per

*Value is measured via oral route in mouse

Compound Information

Psilocybine (Also known as: Psilocybine, Indocybin, Psilocin Phosphate Ester) is a hallucinogenic substance found in certain mushrooms, specifically the major hallucinogenic alkaloid isolated from Psilocybe mushrooms (also known as Teonanacatl or "magic mushrooms"). It has a role as a hallucinogen, a fungal metabolite, a prodrug and a serotonergic agonist. It is currently being tested in clinical trials as a treatment for various types of pain management and depressive symptoms. It is absorbed via ingestion.

Molecular weight: 284.25Chemical formula: C₁₂H₁₇N₂O₄P

Information presented on this page is purely for research purposes only. It is NOT intended for clinical or diagnostic applications. To request additional information and datasets for Psilocybin, please contact info@aatbio.com.

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References

This online resource may be cited as follows

MLA	"Quest Database™ Psilocybin Toxicity (LD50)." AAT Bioquest, Inc., 1 Nov. 2025, https://www.aatbio.com/resources/toxicity-lethality-median-dose-td50-ld50/psilocybin.
APA	AAT Bioquest, Inc. (2025, November 1). Quest Database™ Psilocybin Toxicity (LD50). AAT Bioquest. https://www.aatbio.com/resources/toxicity-lethality-median-dose-td50-ld50/psilocybin.
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