Tetrodotoxin Toxicity (LD50)

The median lethal dose (LD50) for Tetrodotoxin is

0.334 mg

per

*Value is measured via oral route in mice

Compound Information

Tetrodotoxin (Also known as: Maculotoxin, Tarichatoxin, TTX) is one of the most potent and oldest known naturally-occurring neurotoxins. There is no known antidote. Tetrodotoxin binds to the pores of fast voltage-gated fast sodium channels in nerve cell membranes, inhibiting nerve action potentials and blocking nerve transmission. Although found in various species of fish (such as the pufferfish), newts, frogs, flatworms, and crabs, it is actually produced by bacteria such as Vibrio alginolyticus, Pseudoalteromonas tetraodonis<'em>, and other vibrio and pseudomonas bacterial species. It is absorbed via ingestion.

Molecular weight: 319.27Chemical formula: C₁₁H₁₇N₃O₈

Information presented on this page is purely for research purposes only. It is NOT intended for clinical or diagnostic applications. To request additional information and datasets for Tetrodotoxin, please contact info@aatbio.com.

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References

This online resource may be cited as follows

MLA	"Quest Database™ Tetrodotoxin Toxicity (LD50)." AAT Bioquest, Inc., 26 Sep. 2025, https://www.aatbio.com/resources/toxicity-lethality-median-dose-td50-ld50/tetrodotoxin.
APA	AAT Bioquest, Inc. (2025, September 26). Quest Database™ Tetrodotoxin Toxicity (LD50). AAT Bioquest. https://www.aatbio.com/resources/toxicity-lethality-median-dose-td50-ld50/tetrodotoxin.
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