BTA-1 [2-(4'-(methylamino)phenyl)benzothiazole]

BTA-1

2-(4'-(methylamino)phenyl)benzothiazole

BTA-1 is a fluorescent Thioflavin-T derivative that exhibits high affinity for amyloid deposits (Ki = 11 nM for Ab 40). It crosses the blood brain barrier and displays up to 50-fold higher affinity than Thioflavin-T, and used for selectively staining cerebral plaques and cerebrovascular amyloid deposits in the brains of PS1/APP transgenic mice.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
23051	5 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of BTA-1 [2-(4'-(methylamino)phenyl)benzothiazole] to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	416.112 µL	2.081 mL	4.161 mL	20.806 mL	41.611 mL
5 mM	83.222 µL	416.112 µL	832.224 µL	4.161 mL	8.322 mL
10 mM	41.611 µL	208.056 µL	416.112 µL	2.081 mL	4.161 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	240.32 g/mol	=	mL	x	mM	=	mmol

References

View all 7 references: Citation Explorer

Mechanism of A beta(1-40) fibril-induced fluorescence of (trans,trans)-1-bromo-2,5-bis(4-hydroxystyryl)benzene (K114)

Authors:

LeVine H, 3rd.

Journal:

Biochemistry (2005): 15937

Multiple ligand binding sites on A beta(1-40) fibrils

Authors:

LeVine H, 3rd.

Journal:

Amyloid (2005): 5

Efficient radiosynthesis of carbon-11 labelled uncharged Thioflavin T derivatives using [11C]methyl triflate for beta-amyloid imaging in Alzheimer's Disease with PET

Authors:

Solbach C, Uebele M, Reischl G, Machulla HJ.

Journal:

Appl Radiat Isot (2005): 591

Amyloid imaging probes are useful for detection of prion plaques and treatment of transmissible spongiform encephalopathies

Authors:

Ishikawa K, Doh-ura K, Kudo Y, Nishida N, Murakami-Kubo I, Ando Y, Sawada T, Iwaki T.

Journal:

J Gen Virol (2004): 1785

Development of a PET/SPECT agent for amyloid imaging in Alzheimer's disease

Authors:

Wang Y, Klunk WE, Debnath ML, Huang GF, Holt DP, Shao L, Mathis CA.

Journal:

J Mol Neurosci (2004): 55

Physical properties

Molecular weight	240.32
Solvent	DMSO

Spectral properties

Excitation (nm)	349
Emission (nm)	421

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12352200

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Page updated on October 12, 2025