BTA-2 [2-(4'-(dimethylamino)phenyl)-6-methyl-benzothiazole]

BTA-2

2-(4'-(dimethylamino)phenyl)-6-methyl-benzothiazole

BTA-2 is an uncharged derivative of Thioflavin-T that exhibits high affinity for amyloid deposits [Ki = 143 nM for Ab(1-40)] and can cross the blood brain barrier. It displays up to 6-fold higher affinity than ThT and stains both plaques and neurofibrillary tangles in post mortem Alzheimer's disease brain.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
23052	25 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of BTA-2 [2-(4'-(dimethylamino)phenyl)-6-methyl-benzothiazole] to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	372.606 µL	1.863 mL	3.726 mL	18.63 mL	37.261 mL
5 mM	74.521 µL	372.606 µL	745.212 µL	3.726 mL	7.452 mL
10 mM	37.261 µL	186.303 µL	372.606 µL	1.863 mL	3.726 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	268.38 g/mol	=	mL	x	mM	=	mmol

References

View all 7 references: Citation Explorer

Mechanism of A beta(1-40) fibril-induced fluorescence of (trans,trans)-1-bromo-2,5-bis(4-hydroxystyryl)benzene (K114)

Authors:

LeVine H, 3rd.

Journal:

Biochemistry (2005): 15937

Multiple ligand binding sites on A beta(1-40) fibrils

Authors:

LeVine H, 3rd.

Journal:

Amyloid (2005): 5

Efficient radiosynthesis of carbon-11 labelled uncharged Thioflavin T derivatives using [11C]methyl triflate for beta-amyloid imaging in Alzheimer's Disease with PET

Authors:

Solbach C, Uebele M, Reischl G, Machulla HJ.

Journal:

Appl Radiat Isot (2005): 591

Amyloid imaging probes are useful for detection of prion plaques and treatment of transmissible spongiform encephalopathies

Authors:

Ishikawa K, Doh-ura K, Kudo Y, Nishida N, Murakami-Kubo I, Ando Y, Sawada T, Iwaki T.

Journal:

J Gen Virol (2004): 1785

Development of a PET/SPECT agent for amyloid imaging in Alzheimer's disease

Authors:

Wang Y, Klunk WE, Debnath ML, Huang GF, Holt DP, Shao L, Mathis CA.

Journal:

J Mol Neurosci (2004): 55

Physical properties

Molecular weight	268.38
Solvent	DMSO

Spectral properties

Excitation (nm)	355
Emission (nm)	426

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12352200
CAS	10205-62-6

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Page updated on October 13, 2025