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BTA-2 [2-(4'-(dimethylamino)phenyl)-6-methyl-benzothiazole]

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InternationalSee distributors
ShippingStandard overnight for United States, inquire for international
Physical properties
Molecular weight268.38
Spectral properties
Excitation (nm)355
Emission (nm)426
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure


Molecular weight
Excitation (nm)
Emission (nm)
BTA-2 is an uncharged derivative of Thioflavin-T that exhibits high affinity for amyloid deposits [Ki = 143 nM for Ab(1-40)] and can cross the blood brain barrier. It displays up to 6-fold higher affinity than ThT and stains both plaques and neurofibrillary tangles in post mortem Alzheimer's disease brain.


Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of BTA-2 [2-(4'-(dimethylamino)phenyl)-6-methyl-benzothiazole] to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM372.606 µL1.863 mL3.726 mL18.63 mL37.261 mL
5 mM74.521 µL372.606 µL745.212 µL3.726 mL7.452 mL
10 mM37.261 µL186.303 µL372.606 µL1.863 mL3.726 mL

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Spectral properties

Excitation (nm)355
Emission (nm)426



View all 7 references: Citation Explorer
Efficient radiosynthesis of carbon-11 labelled uncharged Thioflavin T derivatives using [11C]methyl triflate for beta-amyloid imaging in Alzheimer's Disease with PET
Authors: Solbach C, Uebele M, Reischl G, Machulla HJ.
Journal: Appl Radiat Isot (2005): 591
Multiple ligand binding sites on A beta(1-40) fibrils
Authors: LeVine H, 3rd.
Journal: Amyloid (2005): 5
Mechanism of A beta(1-40) fibril-induced fluorescence of (trans,trans)-1-bromo-2,5-bis(4-hydroxystyryl)benzene (K114)
Authors: LeVine H, 3rd.
Journal: Biochemistry (2005): 15937
In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET
Authors: Verhoeff NP, Wilson AA, Takeshita S, Trop L, Hussey D, Singh K, Kung HF, Kung MP, Houle S.
Journal: Am J Geriatr Psychiatry (2004): 584
Development of a PET/SPECT agent for amyloid imaging in Alzheimer's disease
Authors: Wang Y, Klunk WE, Debnath ML, Huang GF, Holt DP, Shao L, Mathis CA.
Journal: J Mol Neurosci (2004): 55
Amyloid imaging probes are useful for detection of prion plaques and treatment of transmissible spongiform encephalopathies
Authors: Ishikawa K, Doh-ura K, Kudo Y, Nishida N, Murakami-Kubo I, Ando Y, Sawada T, Iwaki T.
Journal: J Gen Virol (2004): 1785
The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component
Authors: Klunk WE, Wang Y, Huang GF, Debnath ML, Holt DP, Shao L, Hamilton RL, Ikonomovic MD, DeKosky ST, Mathis CA.
Journal: J Neurosci (2003): 2086