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BTA-2 [2-(4'-(dimethylamino)phenyl)-6-methyl-benzothiazole]
Ordering information
| Price | |
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Additional ordering information
| Telephone | 1-800-990-8053 |
| Fax | 1-800-609-2943 |
| sales@aatbio.com | |
| International | See distributors |
| Bulk request | Inquire |
| Custom size | Inquire |
| Shipping | Standard overnight for United States, inquire for international |
Physical properties
| Molecular weight | 268.38 |
| Solvent | DMSO |
Spectral properties
| Excitation (nm) | 355 |
| Emission (nm) | 426 |
Storage, safety and handling
| H-phrase | H303, H313, H333 |
| Hazard symbol | XN |
| Intended use | Research Use Only (RUO) |
| R-phrase | R20, R21, R22 |
| Storage | Freeze (< -15 °C); Minimize light exposure |
| UNSPSC | 12352200 |
| Overview |  SDSProtocol |
CAS 10205-62-6 | Molecular weight 268.38 | Excitation (nm) 355 | Emission (nm) 426 |
BTA-2 is an uncharged derivative of Thioflavin-T that exhibits high affinity for amyloid deposits [Ki = 143 nM for Ab(1-40)] and can cross the blood brain barrier. It displays up to 6-fold higher affinity than ThT and stains both plaques and neurofibrillary tangles in post mortem Alzheimer's disease brain.
Calculators
Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of BTA-2 [2-(4'-(dimethylamino)phenyl)-6-methyl-benzothiazole] to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 372.606 µL | 1.863 mL | 3.726 mL | 18.63 mL | 37.261 mL |
| 5 mM | 74.521 µL | 372.606 µL | 745.212 µL | 3.726 mL | 7.452 mL |
| 10 mM | 37.261 µL | 186.303 µL | 372.606 µL | 1.863 mL | 3.726 mL |
Molarity calculator
Enter any two values (mass, volume, concentration) to calculate the third.
| Mass (Calculate) | Molecular weight | Volume (Calculate) | Concentration (Calculate) | Moles | ||||
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Product Family
| Name | Excitation (nm) | Emission (nm) |
| 2-Aminoacridone *CAS 27918-14-5* | 429 | 529 |
| BTA-1 [2-(4'-(methylamino)phenyl)benzothiazole] | 349 | 421 |
| 2-NBDG [2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose] *CAS#: 186689-07-6* | 467 | 538 |
Images
Figure 1. Chemical structure for BTA-2 [2-(4'-(dimethylamino)phenyl)-6-methyl-benzothiazole]
References
View all 7 references: Citation Explorer
Efficient radiosynthesis of carbon-11 labelled uncharged Thioflavin T derivatives using [11C]methyl triflate for beta-amyloid imaging in Alzheimer's Disease with PET
Authors: Solbach C, Uebele M, Reischl G, Machulla HJ.
Journal: Appl Radiat Isot (2005): 591
Authors: Solbach C, Uebele M, Reischl G, Machulla HJ.
Journal: Appl Radiat Isot (2005): 591
Multiple ligand binding sites on A beta(1-40) fibrils
Authors: LeVine H, 3rd.
Journal: Amyloid (2005): 5
Authors: LeVine H, 3rd.
Journal: Amyloid (2005): 5
Mechanism of A beta(1-40) fibril-induced fluorescence of (trans,trans)-1-bromo-2,5-bis(4-hydroxystyryl)benzene (K114)
Authors: LeVine H, 3rd.
Journal: Biochemistry (2005): 15937
Authors: LeVine H, 3rd.
Journal: Biochemistry (2005): 15937
In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET
Authors: Verhoeff NP, Wilson AA, Takeshita S, Trop L, Hussey D, Singh K, Kung HF, Kung MP, Houle S.
Journal: Am J Geriatr Psychiatry (2004): 584
Authors: Verhoeff NP, Wilson AA, Takeshita S, Trop L, Hussey D, Singh K, Kung HF, Kung MP, Houle S.
Journal: Am J Geriatr Psychiatry (2004): 584
Development of a PET/SPECT agent for amyloid imaging in Alzheimer's disease
Authors: Wang Y, Klunk WE, Debnath ML, Huang GF, Holt DP, Shao L, Mathis CA.
Journal: J Mol Neurosci (2004): 55
Authors: Wang Y, Klunk WE, Debnath ML, Huang GF, Holt DP, Shao L, Mathis CA.
Journal: J Mol Neurosci (2004): 55
Amyloid imaging probes are useful for detection of prion plaques and treatment of transmissible spongiform encephalopathies
Authors: Ishikawa K, Doh-ura K, Kudo Y, Nishida N, Murakami-Kubo I, Ando Y, Sawada T, Iwaki T.
Journal: J Gen Virol (2004): 1785
Authors: Ishikawa K, Doh-ura K, Kudo Y, Nishida N, Murakami-Kubo I, Ando Y, Sawada T, Iwaki T.
Journal: J Gen Virol (2004): 1785
The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component
Authors: Klunk WE, Wang Y, Huang GF, Debnath ML, Holt DP, Shao L, Hamilton RL, Ikonomovic MD, DeKosky ST, Mathis CA.
Journal: J Neurosci (2003): 2086
Authors: Klunk WE, Wang Y, Huang GF, Debnath ML, Holt DP, Shao L, Hamilton RL, Ikonomovic MD, DeKosky ST, Mathis CA.
Journal: J Neurosci (2003): 2086