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Crotonaldehyde BSA Conjugate

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Physical properties
SolventWater
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
UNSPSC12171501
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OverviewpdfSDSpdfProtocol


Crotonaldehyde is a common environmental pollutant. Inhalation of tobbacco smoke is a significant source of crotonaldehyde, exposing smokers to 30−170 μg/kg/day. Crotonaldehyde also occurs naturally in certain fruits and vegetables, selected dairy products, and some alcoholic beverages. In addition to these exogenous sources, crotonaldehyde is also formed endogenously during lipid peroxidation (LPO), a factor that may contribute to the aldehydes' presence in the serum of nonsmokers. As with other unsaturated aldehydes, crotonaldehyde exhibits many toxicological properties, including an ability to cause multi-organ toxicity in laboratory animals; DNA damage and mutagenicity in vitro; and carcinogenicity in vivo. Crotonaldehyde BSA conjugate was carefully prepared from the addition of crotonaldehyde to bovine serum albumin (BSA). Our crotonaldehyde BSA conjugate is fully characterized with the defined ratio of crotonaldehyde/protein that is not provided by other vendors. It has been used for preparing anti-crotonaldehyde antibodies and for developing crotonaldehyde-quantifying assays.

References


View all 8 references: Citation Explorer
Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.
Authors: Park, Sungshim L and Carmella, Steven G and Chen, Menglan and Patel, Yesha and Stram, Daniel O and Haiman, Christopher A and Le Marchand, Loic and Hecht, Stephen S
Journal: PloS one (2015): e0124841
Tandem catalysis in domino olefin cross-metathesis/intramolecular oxa-conjugate cyclization: concise synthesis of 2,6-cis-substituted tetrahydropyran derivatives.
Authors: Fuwa, Haruhiko and Noguchi, Takuma and Noto, Kenkichi and Sasaki, Makoto
Journal: Organic & biomolecular chemistry (2012): 8108-12
The organocatalytic three-step total synthesis of (+)-frondosin B.
Authors: Reiter, Maud and Torssell, Staffan and Lee, Sandra and Macmillan, David W C
Journal: Chemical science (2010): 37-42
Kinetics and mechanism of protein tyrosine phosphatase 1B inactivation by acrolein.
Authors: Seiner, Derrick R and LaButti, Jason N and Gates, Kent S
Journal: Chemical research in toxicology (2007): 1315-20
Nucleophilic carbenes as organocatalysts.
Authors: Glorius, F and Hirano, K
Journal: Ernst Schering Foundation symposium proceedings (2007): 159-81
Coupling products of nucleosides with the glyoxal adduct of deoxyguanosine.
Authors: Brock, Angela K and Kozekov, Ivan D and Rizzo, Carmelo J and Harris, Thomas M
Journal: Chemical research in toxicology (2004): 1047-56
Structural and kinetic determinants of aldehyde reduction by aldose reductase.
Authors: Srivastava, S and Watowich, S J and Petrash, J M and Srivastava, S K and Bhatnagar, A
Journal: Biochemistry (1999): 42-54
Inhibition of glutathione S-transferase activity in human melanoma cells by alpha,beta-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal.
Authors: Iersel, M L and Ploemen, J P and Struik, I and van Amersfoort, C and Keyzer, A E and Schefferlie, J G and van Bladeren, P J
Journal: Chemico-biological interactions (1996): 117-32