Crotonaldehyde HSA (Human Serum Albumin) Conjugate

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Water

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

Overview SDS Protocol

Crotonaldehyde is a common environmental pollutant, formed upon combustion of fossil fuels and wood. Inhalation of tobbacco smoke is also a significant source of crotonaldehyde. Crotonaldehyde exhibits many toxicological properties, including an ability to cause multi-organ toxicity in laboratory animals; DNA damage and mutagenicity in vitro; and carcinogenicity in vivo. As a reactive bifunctional electrophile, crotonaldehyde readily generates adducts in a range of cell macromolecules. Crotonaldehyde human serum albumin(HAS) conjugate was fully characterized, and has been used for developing crotonaldehyde-quantifying assays.

References

View all 50 references: Citation Explorer

Resolution and Quantitation of Mercapturic Acids Derived from Crotonaldehyde, Methacrolein, and Methyl Vinyl Ketone in the Urine of Smokers and Nonsmokers.
Authors: Chen, Menglan and Carmella, Steven G and Li, Yupeng and Zhao, Yingchun and Hecht, Stephen S
Journal: Chemical research in toxicology (2020): 669-677

Crotonaldehyde-induced alterations in testicular enzyme function and hormone levels, and apoptosis in the testes of male Wistar rats are associated with oxidative damage.
Authors: Zhang, Biao and Wei, Ping and Men, Jinlong and Zhang, Shuman and Shao, Hua and Zhang, Zhihu
Journal: Toxicology mechanisms and methods (2020): 19-32

A computational foray into the mechanism and catalysis of the adduct formation reaction of guanine with crotonaldehyde.
Authors: Kroeger, Asja A and Karton, Amir
Journal: Journal of computational chemistry (2019): 630-637

[Study on lung injury induced by subchronic exposure to crotonaldehyde in male rats].
Authors: Li, S S and Zhang, B and Zhang, S M and Zhang, Z H and Wei, Y N
Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygie (2019): 728-731

Autophagy in Crotonaldehyde-Induced Endothelial Toxicity.
Authors: Lee, Seung Eun and Park, Hye Rim and Park, Cheung-Seog and Ahn, Hyun-Jong and Cho, Jeong-Je and Lee, Jongsung and Park, Yong Seek
Journal: Molecules (Basel, Switzerland) (2019)

Effect of influent pH on hydrolytic acidification performance and bacterial community structure in EGSB for pretreating crotonaldehyde manufacture wastewater after ozonation.
Authors: Liu, Tao and Shen, Zhiqiang and Zhang, Chunyu and Song, Yudong and Li, Jie and Yang, Zongpu and Song, Guangqing and Han, Zhenfeng and Zhou, Yuexi
Journal: Water science and technology : a journal of the International Association on Water Pollution Research (2019): 1174-1183

Autophagy induced by low concentrations of crotonaldehyde promotes apoptosis and inhibits necrosis in human bronchial epithelial cells.
Authors: Wang, Limeng and Li, Xiang and Yang, Zhihua and Zhu, Maoxiang and Xie, Jianping
Journal: Ecotoxicology and environmental safety (2019): 169-177

Toxic trans-crotonaldehyde in mitochondria intercepted by oxyresveratrol contributing to anticancer.
Authors: Su, Yanbin and Sun, Chengyu and Chen, Yan and Liu, Shichang and Jing, Ning and Li, Shuxin
Journal: IUBMB life (2019): 1014-1020

[Study on oxidative stress damage of reproductive organs in male rats induced by long-term exposure to crotonaldehyde].
Authors: Li, S S and Zhang, B and Zhang, Z H
Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygie (2019): 241-246

Long-term exposure to crotonaldehyde causes heart and kidney dysfunction through induction of inflammatory and oxidative damage in male Wistar rats.
Authors: Zhang, Biao and Li, Shuangshuang and Men, Jinlong and Peng, Cheng and Shao, Hua and Zhang, Zhihu
Journal: Toxicology mechanisms and methods (2019): 263-275