Name: FAM-beta-Amyloid (1-42) [beta-Amyloid (1-42), 5-FAM-Labeled]
Brand: AAT Bioquest
SKU: 81111
Price: 128 USD
Availability: InStock

FAM-beta-Amyloid (1-42)

beta-Amyloid (1-42), 5-FAM-Labeled

5-FAM-beta-Amyloid (1-42) is a 5-FAM-labeled peptide used extensively in neuroscience research, particularly in studies related to Alzheimer’s disease.

Sequence Length: 42 amino acids from the N-terminal region of the full Aβ peptide
Biomarker: It is used as a highly accurate diagnostic marker for AD pathology
Spectral Compatibility: Well excited at 488 nm, a common setting for fluorescence microscopy or flow cytometry

Effects of LPS treatment on cellular uptake of 5-FAM beta amyloid 1-42 (Cat# 81111) in HeLa cells. HeLa cells were incubated with 5-FAM–labeled beta-amyloid (1–42) (Cat# 81111) in the presence or absence of LPS (200 nM) for 20 h at 37 °C. Cells were subsequently stained with Nuclear Red LCS1 (Cat# 17542) and imaged using FITC and Cy5 filter sets. LPS treatment increased intracellular punctate 5-FAM fluorescence relative to untreated controls, consistent with enhanced cellular uptake and/or accumulation of beta-amyloid (1–42).

Datasheet

SDS

COA

Catalog	Size	Price	Quantity
81111	100 ug	Price

Overview

5-FAM-beta-Amyloid (1-42) is a 5-FAM-labeled peptide used extensively in neuroscience research, particularly in studies related to Alzheimer’s disease. 5-FAM tag is conjugated to the N-termini of beta-Amyloid (1-42) peptide with sequence: 5-FAM-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH (DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA). It has a green fluorescence. The spectral properties of 5-FAM label allow researchers to visualize and track the fluorescent peptide in biological systems using the most common settings either in a fluorescence microscope or flow cytometer. AAT Bioquest’s 5-FAM-beta-Amyloid (1-42) material is thoroughly analyzed to ensure its quality by HPLC, electrophoresis and cell functional analysis. Beta-Amyloid (1-42) is a peptide fragment derived from the amyloid precursor protein (APP). It is the primary component of amyloid plaques found in the brains of individuals with Alzheimer’s disease. Beta-Amyloid (1-42) is used in neurotoxicity, neuroinflammation and drug screening studies. Aβ(1-42) aggregates into fibrils and oligomers that are neurotoxic.

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of FAM-beta-Amyloid (1-42) [beta-Amyloid (1-42), 5-FAM-Labeled] to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	18.008 µL	90.038 µL	180.076 µL	900.382 µL	1.801 mL
5 mM	3.602 µL	18.008 µL	36.015 µL	180.076 µL	360.153 µL
10 mM	1.801 µL	9.004 µL	18.008 µL	90.038 µL	180.076 µL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	5553.2 g/mol	=	mL	x	mM	=	mmol

References

View all 50 references: Citation Explorer

Advances and future trends in the detection of beta-amyloid: A comprehensive review.

Authors:

Ganguly, Atri and Babu, Srivalliputtur Sarath and Ghosh, Sumanta and Velyutham, Ravichandiran and Kapusetti, Govinda

Journal:

Medical engineering & physics (2025): 104269

PU.1 dictates β-amyloid-induced TREM2 expression upregulation in microglia in a transgenic model of Alzheimer's disease.

Authors:

Wei, Zhen and Pan, Xiaodong and Cui, Xiaoli and Zhang, Jing and Dai, Xiaoman and Zeng, Yuqi and Chen, Xiaochun

Journal:

Frontiers in aging neuroscience (2025): 1537388

Fluorescent aptasensor based on target-induced hairpin conformation switch coupled with nicking enzyme-assisted signal amplification for detection of beta-amyloid oligomers in cerebrospinal fluid.

Authors:

Chuang, Wan-Chen and Chen, Chun-Hsien and Duh, Tsai-Hui and Chen, Yen-Ling

Journal:

Mikrochimica acta (2025): 70

Silica-coated gold nanorods conjugated with CRANAD to improve the detection of soluble β-amyloid species via a surface-enhanced fluorescence effect.

Authors:

Oyarzún, María Paz and Cabrera, Pablo and Parra-Muñoz, Nicole and López-Monsalves, Valentina and Riveros, Ana Luisa and Celis, Freddy and Gimeno-Muñoz, Raquel and González-Campo, Arántzazu and Aliaga-Alcalde, Núria and Soler, Mónica and Kogan, Marcelo J

Journal:

Colloids and surfaces. B, Biointerfaces (2025): 114660

Alterations of endocannabinoid signaling and microglia reactivity in the retinas of AD-like mice precede the onset of hippocampal β-amyloid plaques.

Authors:

Tisi, Annamaria and Scipioni, Lucia and Carozza, Giulia and Di Re, Lucia and Cimino, Giacomo and Di Meo, Camilla and Palaniappan, Sakthimala and Valle, Francesco Della and Fanti, Federico and Giacovazzo, Giacomo and Compagnone, Dario and Maccarone, Rita and Oddi, Sergio and Maccarrone, Mauro

Journal:

Journal of neurochemistry (2025): e16256

Physical properties

Molecular weight	5553.20
Solvent	DMSO

Spectral properties

Correction factor (260 nm)	0.32
Correction factor (280 nm)	0.178
Extinction coefficient (cm ^-1 M ^-1)	83000
Excitation (nm)	493
Emission (nm)	517

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure

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Page updated on April 14, 2026