Name: FAM-LETD-FMK
Brand: AAT Bioquest
SKU: 13416
Price: 290 USD
Availability: InStock

FAM-LETD-FMK

Activation of caspases plays a central role in apoptosis. FAM-LETD-FMK provides a convenient means for sensitive detection of activated caspase-8 in living cells. It is cell permeable, nontoxic, and irreversibly binds to activated caspase-8 in apoptotic cells. The FAM label allows for direct detection of activated caspases in apoptotic cells by fluorescence microscopy, flow cytometry, or fluorescence plate reader.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
13416	100 ug	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of FAM-LETD-FMK to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	117.535 µL	587.675 µL	1.175 mL	5.877 mL	11.754 mL
5 mM	23.507 µL	117.535 µL	235.07 µL	1.175 mL	2.351 mL
10 mM	11.754 µL	58.768 µL	117.535 µL	587.675 µL	1.175 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	850.81 g/mol	=	mL	x	mM	=	mmol

References

View all 4 references: Citation Explorer

Antitumor mechanism of 3-bromopropionylamino benzoylurea on leukemia and lymphoma

Authors:

Li JN, Song DQ, Jiang JD.

Journal:

Yao Xue Xue Bao (2004): 491

Activation of caspase-like activity and poly (ADP-ribose) polymerase degradation during sporulation in Aspergillus nidulans

Authors:

Thrane C, Kaufmann U, Stummann BM, Olsson S.

Journal:

Fungal Genet Biol (2004): 361

Caspase-dependent and independent cell death in rat hepatoma 5123tc cells

Authors:

P, undefined and ey S, Smith B, Walker PR, Sikorska M.

Journal:

Apoptosis (2000): 265

C-myc antisense oligodeoxynucleotides can induce apoptosis and down-regulate Fas expression in rheumatoid synoviocytes

Authors:

Hashiramoto A, Sano H, Maekawa T, Kawahito Y, Kimura S, Kusaka Y, Wilder RL, Kato H, Kondo M, Nakajima H.

Journal:

Arthritis Rheum (1999): 954

Physical properties

Molecular weight	850.81
Solvent	DMSO

Spectral properties

Correction factor (260 nm)	0.32
Correction factor (280 nm)	0.178
Extinction coefficient (cm ^-1 M ^-1)	83000
Excitation (nm)	493
Emission (nm)	517

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12352200

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Page updated on October 13, 2025