iFluor® 488 Anti-human CD4 Antibody *OKT-4*

OKT-4 is an anti-human monoclonal antibody that targets the CD4 antigen. CD4 (also known as T4) is a 55 kD member of the Ig superfamily that is located on the surface of cells such as macrophages. In certain organisms, CD4 positively regulates kinase activity, promotes I-kappaB kinase/NF-kappaB signaling and upregulates transcription, DNA-templated. Additionally, it has been thought to be involved with essential biological processes such as immune response, especially adaptive immune response. CD4 is a member of critical cellular pathways, for instance, the cytokine-mediated signaling pathway, enzyme linked receptor protein signaling pathway and interleukin-15-mediated signaling pathway. From a research standpoint, it is of biological interest due to its association with key macromolecules/ligands like Lck and IL-16. CD4 is a very popular antibody target, with over 185000 publications in the last decade. CD4 is frequently used in flow cytometry applications as a phenotypic marker for differentiation of cell types, especially in the study of immunology. This antibody was purified through affinity chromatography and conjugated to iFluor® 488 (ex/em = 491/516 nm). It is compatible with the 488 nm laser and 525/45 nm bandpass filter (for example, as in the Agilent Technologies NovoCyte Advanteon).