iFluor® A7 Anti-human CD34 Antibody *4H11*

4H11 is an anti-human monoclonal antibody that recognizes the CD34 antigen. CD34 (sometimes called Gp105-120) is a 105 - 120 kD glycoprotein that is located on the surface of cells like endothelial cells and stem cells. In many organisms, CD34 plays a role in the downregulation of tumor necrosis factor production, positively regulates granulocyte colony-stimulating factor production and is involved in the positive regulation of vasculogenesis. Also, it has been associated with vital biological processes such as endothelium development, especially glomerular endothelium development. From a research standpoint, it is of biological interest due to its association with critical macromolecules/ligands like MadCAM-1, CRKL and L-Selectin. CD34 is a very popular antibody target, with over 55000 publications in the last decade. CD34 is vital to neuroscience, neuroinflammation and immunology research, typically serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography and conjugated to iFluor® A7.